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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Microparticles from patients with systemic lupus erythematosus induce production of reactive oxygen species and degranulation of polymorphonuclear leukocytes

Fig. 4

Influence of exogenously added IgG on MP-induced ROS production by PMNs. Leukocytes purified from three healthy blood group 0 donors were stimulated with autologous MPs, alone (open symbols) or in combination with LPS (closed symbols), in the presence of autologous serum supplemented with various amounts of IgG from SLE patients (SLE IgG) or healthy donors (IVIg). DHR was used as probe for H2O2 production. Shown is the resulting median fluorescence intensity (MFI) of PMNs, as measured by flow cytometry. Symbols represent average and error bars represent range. IgG immunoglobulin G, LPS lipopolysaccharide, MP microparticle, SLE systemic lupus erythematosus

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Arthritis Research & Therapy

ISSN: 1478-6362

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