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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

Fig. 1

CD11c+ B cells were increased in cGVHD mice. B6 mice (n = 5) received an intraperitoneal injection of 5 × 107 splenocytes from Bm12 or B6 mice; spleens and serum were collected at day 14 for flow analysis and the antibodies examination. a Weight and cell counts of the spleen were taken 14 days later. The figure shows spleen photographs, spleen weight, and absolute number of splenocytes. b Serum antichromatin total IgG and IgG subtype titers were examined by ELISA. c, d Flow cytometric analysis of CD11c+CD19+ cells (c) and CD11c+CD138+ cells (d) in total spleen. Values are shown as the mean ± SD. **P < 0.01, ***P < 0.001, ****P < 0.0001. Abs antibodies, IgG immunoglobulin G, OD optical density

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