Skip to main content


Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

Fig. 2

CD11c+ plasma cells in cGVHD mice produced antichromatin antibodies after stimulation in vitro. CD11c+CD138+ and CD11cCD138+ cells were sorted from cGVHD mice and cultured for 7 days in the presence of the TLR4 (lipopolysaccharide; LPS) or TLR7 agonist (R848). Antichromatin total IgG (a) and antichromatin IgG subclass (b) in the supernatant were subsequently measured by ELISA. In (a), the x-axis shows the dilution factors. Bars represent mean (± SD) of three independent experiments. *P < 0.05, **P < 0.01. IgG immunoglobulin G, ns not significant, OD optical density

Back to article page