Skip to main content

Table 3 Predictivity of anti-C1q antibodies in SLE flares

From: Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review

Number of patients (n)

Findings

Study

68

For renal flares: sensitivity 71%, specificity 92%, PPV 50%, NPV 97%

Siegert et al., 1993 [40]

151

10 of 14 patients who developed proliferative nephritis had significant increases in anti-C1q level

Coremans et al., 1995 [15]

151

NPV 100% for nephritis

Marto et al., 2005 [39]

70

For severe lupus nephritis: sensitivity 100%, specificity 95.7%, PPV 50%, NPV 100%

Meyer et al., 2009 [30]

23

For renal flares: sensitivity 75.7%, specificity 84%, PPV 56%, NPV 70%

Matrat et al., 2011 [29]

  1. All anti-C1q antibodies were measured using enzyme-linked immunosorbent assays
  2. NPV negative predictive value, PPV positive predictive value, SLE systemic lupus erythematosus