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Table 3 Predictivity of anti-C1q antibodies in SLE flares

From: Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review

Number of patients (n) Findings Study
68 For renal flares: sensitivity 71%, specificity 92%, PPV 50%, NPV 97% Siegert et al., 1993 [40]
151 10 of 14 patients who developed proliferative nephritis had significant increases in anti-C1q level Coremans et al., 1995 [15]
151 NPV 100% for nephritis Marto et al., 2005 [39]
70 For severe lupus nephritis: sensitivity 100%, specificity 95.7%, PPV 50%, NPV 100% Meyer et al., 2009 [30]
23 For renal flares: sensitivity 75.7%, specificity 84%, PPV 56%, NPV 70% Matrat et al., 2011 [29]
  1. All anti-C1q antibodies were measured using enzyme-linked immunosorbent assays
  2. NPV negative predictive value, PPV positive predictive value, SLE systemic lupus erythematosus