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Table 4 Predictivity of anti-ENA in SLE flares

From: Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review

Biomarker(s) Number of patients (n) Findings Study
Anti-Sm ab, ANA 110 Presence of anti-Sm ab at baseline was found at a higher incidence in patients developing exacerbation(s) Swaak et al., 1989 [5]
ANA 120 ANA titre was associated with flares in the subsequent year Mirzayan et al., 2000 [6]
ANA, anti-nucleosome and anti-histone ab 199 Patients with anti-histone ab (≥ 3 SDs above control mean) at baseline had a higher risk of developing lupus nephritis Cortes-Hernandez et al., 2004 [22]
Anti-nucleosome ab 21 Time to first flare was significantly correlated with the presence of anti-nucleosome and high anti-nucleosome ab titres Ng et al., 2006 [42]
Anti-ENA 32 Baseline anti-ENA was an independent predictor of flare Ng et al., 2007 [36]
ANA, anti-Sm ab 562 Anti-Sm positivity (≥ 15 units/ml) at baseline predicted flares Petri et al., 2013 [9]
Anti-Ro 47 Fluctuations of anti-Ro/SS-A ab levels were not predictive of flares Praprotnik et al., 1999 [43]
Anti-Ro, anti-La, anti-Sm and anti-RNP ab 45 Fluctuations of anti-Ro, anti-La, anti-Sm and anti-RNP were not associated with flares Agarwal et al., 2009 [41]
  1. ab antibody, ANA anti-nuclear antibodies, anti-RNP anti-ribonucleoprotein, anti-ENA anti-extractable nuclear antigen, SD standard deviation, SLE systemic lupus erythematosus