Table 4 Predictivity of anti-ENA in SLE flares
From: Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
Biomarker(s) | Number of patients (n) | Findings | Study |
|---|---|---|---|
Anti-Sm ab, ANA | 110 | Presence of anti-Sm ab at baseline was found at a higher incidence in patients developing exacerbation(s) | Swaak et al., 1989 [5] |
ANA | 120 | ANA titre was associated with flares in the subsequent year | Mirzayan et al., 2000 [6] |
ANA, anti-nucleosome and anti-histone ab | 199 | Patients with anti-histone ab (≥ 3 SDs above control mean) at baseline had a higher risk of developing lupus nephritis | Cortes-Hernandez et al., 2004 [22] |
Anti-nucleosome ab | 21 | Time to first flare was significantly correlated with the presence of anti-nucleosome and high anti-nucleosome ab titres | Ng et al., 2006 [42] |
Anti-ENA | 32 | Baseline anti-ENA was an independent predictor of flare | Ng et al., 2007 [36] |
ANA, anti-Sm ab | 562 | Anti-Sm positivity (≥ 15 units/ml) at baseline predicted flares | Petri et al., 2013 [9] |
Anti-Ro | 47 | Fluctuations of anti-Ro/SS-A ab levels were not predictive of flares | Praprotnik et al., 1999 [43] |
Anti-Ro, anti-La, anti-Sm and anti-RNP ab | 45 | Fluctuations of anti-Ro, anti-La, anti-Sm and anti-RNP were not associated with flares | Agarwal et al., 2009 [41] |