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Table 2 Association between serum Mg and knee chondrocalcinosis in the Xiangya Hospital Health Management Center Study (n = 12,631)

From: Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis

  Tertiles of serum Mg (mmol/L) P for trend
1 (≤0.86) 2 (0.87–0.91) 3 (≥0.92)
Total
N for knee* 9263 7438 8497 -
 Knee chondrocalcinosis (%) 1.3 0.8 0.6 -
 Model 1 (95% CI) 1.00 (reference) 0.59 (0.40, 0.87) 0.49 (0.33, 0.72) <0.001
 Model 2 (95% CI) 1.00 (reference) 0.59 (0.39, 0.89) 0.53 (0.36, 0.78) 0.001
 Model 3 (95% CI) 1.00 (reference) 0.69 (0.36, 1.32) 0.38 (0.20, 0.71) 0.002
 Model 4 (95% CI) 1.00 (reference) 0.60 (0.41, 0.89) 0.48 (0.33, 0.71) <0.001
 Model 5 (95% CI) 1.00 (reference) 0.58 (0.39, 0.88) 0.52 (0.35, 0.78) 0.001
 Model 6 (95% CI) 1.00 (reference) 0.57 (0.38, 0.86) 0.49 (0.33, 0.73) <0.001
 Model 7 (95% CI) 1.00 (reference) 0.60 (0.41, 0.89) 0.48 (0.33, 0.72) <0.001
 Model 8 (95% CI) 1.00 (reference) 0.83 (0.43, 1.58) 0.46 (0.23, 0.90) 0.021
Male
N for knee* 5065 4279 5058 -
 Knee chondrocalcinosis (%) 1.4 0.7 0.5 -
 Model 1 (95% CI) 1.00 (reference) 0.56 (0.33, 0.95) 0.43 (0.25, 0.74) 0.002
 Model 2 (95% CI) 1.00 (reference) 0.54 (0.31, 0.96) 0.45 (0.26, 0.78) 0.003
 Model 3 (95% CI) 1.00 (reference) 0.65 (0.27, 1.56) 0.37 (0.16, 0.84) 0.017
 Model 4 (95% CI) 1.00 (reference) 0.57 (0.34, 0.98) 0.42 (0.24, 0.73) 0.002
 Model 5 (95% CI) 1.00 (reference) 0.54 (0.30, 0.94) 0.45 (0.26, 0.78) 0.003
 Model 6 (95% CI) 1.00 (reference) 0.54 (0.31, 0.94) 0.41 (0.24, 0.72) 0.001
 Model 7 (95% CI) 1.00 (reference) 0.57 (0.33, 0.98) 0.42 (0.24, 0.73) 0.002
 Model 8 (95% CI) 1.00 (reference) 0.92 (0.40, 2.11) 0.51 (0.21, 1.24) 0.134
Female
N for knee* 4198 3159 3494 -
 Knee chondrocalcinosis (%) 1.2 0.9 0.8 -
 Model 1 (95% CI) 1.00 (reference) 0.64 (0.36, 1.13) 0.54 (0.30, 0.96) 0.034
 Model 2 (95% CI) 1.00 (reference) 0.65 (0.36, 1.19) 0.60 (0.33, 1.09) 0.094
 Model 3 (95% CI) 1.00 (reference) 0.78 (0.29, 2.13) 0.41 (0.14, 1.21) 0.091
 Model 4 (95% CI) 1.00 (reference) 0.65 (0.37, 1.15) 0.54 (0.31, 0.96) 0.035
 Model 5 (95% CI) 1.00 (reference) 0.65 (0.36, 1.18) 0.59 (0.33, 1.07) 0.081
 Model 6 (95% CI) 1.00 (reference) 0.65 (0.35, 1.19) 0.60 (0.33, 1.10) 0.096
 Model 7 (95% CI) 1.00 (reference) 0.65 (0.36, 1.14) 0.54 (0.30, 0.96) 0.034
 Model 8 (95% CI) 1.00 (reference) 0.67 (0.24, 1.88) 0.37 (0.13, 1.12) 0.073
  1. Model 1 included age (40–49, 50–59, 60–69, ≥70 years), body mass index (BMI) (<25, ≥25 kg/m2) and sex (age and BMI for the sex subgroup) (n = 12,631)
  2. Model 2 added serum iron (tertiles) on the basis of model 1 (n = 12,149)
  3. Model 3 added serum ferritin (tertiles) on the basis of model 1 (n = 5113)
  4. Model 4 added serum calcium (tertiles) on the basis of model 1 (n = 12,479)
  5. Model 5 added serum zinc (tertiles) on the basis of model 1 (n = 12,154)
  6. Model 6 added serum copper (tertiles) on the basis of model 1 (n = 12,153)
  7. Model 7 added serum phosphorus (tertiles) on the basis of model 1 (n = 12490)
  8. Model 8 added education (high school or above, lower than high school) and occupation (manual labor, non-manual labor) on the basis of model 1 (n = 5844)
  9. *Five right knees and four left knees with Kellgren-Lawrence grade 4were excluded from analysis (data from the contralateral knees were retained)
  10. Mg magnesium, N number, CI confidence interval