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Table 2 Association between serum Mg and knee chondrocalcinosis in the Xiangya Hospital Health Management Center Study (n = 12,631)

From: Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis

 

Tertiles of serum Mg (mmol/L)

P for trend

1 (≤0.86)

2 (0.87–0.91)

3 (≥0.92)

Total

  N for knee*

9263

7438

8497

-

 Knee chondrocalcinosis (%)

1.3

0.8

0.6

-

 Model 1 (95% CI)

1.00 (reference)

0.59 (0.40, 0.87)

0.49 (0.33, 0.72)

<0.001

 Model 2 (95% CI)

1.00 (reference)

0.59 (0.39, 0.89)

0.53 (0.36, 0.78)

0.001

 Model 3 (95% CI)

1.00 (reference)

0.69 (0.36, 1.32)

0.38 (0.20, 0.71)

0.002

 Model 4 (95% CI)

1.00 (reference)

0.60 (0.41, 0.89)

0.48 (0.33, 0.71)

<0.001

 Model 5 (95% CI)

1.00 (reference)

0.58 (0.39, 0.88)

0.52 (0.35, 0.78)

0.001

 Model 6 (95% CI)

1.00 (reference)

0.57 (0.38, 0.86)

0.49 (0.33, 0.73)

<0.001

 Model 7 (95% CI)

1.00 (reference)

0.60 (0.41, 0.89)

0.48 (0.33, 0.72)

<0.001

 Model 8 (95% CI)

1.00 (reference)

0.83 (0.43, 1.58)

0.46 (0.23, 0.90)

0.021

Male

  N for knee*

5065

4279

5058

-

 Knee chondrocalcinosis (%)

1.4

0.7

0.5

-

 Model 1 (95% CI)

1.00 (reference)

0.56 (0.33, 0.95)

0.43 (0.25, 0.74)

0.002

 Model 2 (95% CI)

1.00 (reference)

0.54 (0.31, 0.96)

0.45 (0.26, 0.78)

0.003

 Model 3 (95% CI)

1.00 (reference)

0.65 (0.27, 1.56)

0.37 (0.16, 0.84)

0.017

 Model 4 (95% CI)

1.00 (reference)

0.57 (0.34, 0.98)

0.42 (0.24, 0.73)

0.002

 Model 5 (95% CI)

1.00 (reference)

0.54 (0.30, 0.94)

0.45 (0.26, 0.78)

0.003

 Model 6 (95% CI)

1.00 (reference)

0.54 (0.31, 0.94)

0.41 (0.24, 0.72)

0.001

 Model 7 (95% CI)

1.00 (reference)

0.57 (0.33, 0.98)

0.42 (0.24, 0.73)

0.002

 Model 8 (95% CI)

1.00 (reference)

0.92 (0.40, 2.11)

0.51 (0.21, 1.24)

0.134

Female

  N for knee*

4198

3159

3494

-

 Knee chondrocalcinosis (%)

1.2

0.9

0.8

-

 Model 1 (95% CI)

1.00 (reference)

0.64 (0.36, 1.13)

0.54 (0.30, 0.96)

0.034

 Model 2 (95% CI)

1.00 (reference)

0.65 (0.36, 1.19)

0.60 (0.33, 1.09)

0.094

 Model 3 (95% CI)

1.00 (reference)

0.78 (0.29, 2.13)

0.41 (0.14, 1.21)

0.091

 Model 4 (95% CI)

1.00 (reference)

0.65 (0.37, 1.15)

0.54 (0.31, 0.96)

0.035

 Model 5 (95% CI)

1.00 (reference)

0.65 (0.36, 1.18)

0.59 (0.33, 1.07)

0.081

 Model 6 (95% CI)

1.00 (reference)

0.65 (0.35, 1.19)

0.60 (0.33, 1.10)

0.096

 Model 7 (95% CI)

1.00 (reference)

0.65 (0.36, 1.14)

0.54 (0.30, 0.96)

0.034

 Model 8 (95% CI)

1.00 (reference)

0.67 (0.24, 1.88)

0.37 (0.13, 1.12)

0.073

  1. Model 1 included age (40–49, 50–59, 60–69, ≥70 years), body mass index (BMI) (<25, ≥25 kg/m2) and sex (age and BMI for the sex subgroup) (n = 12,631)
  2. Model 2 added serum iron (tertiles) on the basis of model 1 (n = 12,149)
  3. Model 3 added serum ferritin (tertiles) on the basis of model 1 (n = 5113)
  4. Model 4 added serum calcium (tertiles) on the basis of model 1 (n = 12,479)
  5. Model 5 added serum zinc (tertiles) on the basis of model 1 (n = 12,154)
  6. Model 6 added serum copper (tertiles) on the basis of model 1 (n = 12,153)
  7. Model 7 added serum phosphorus (tertiles) on the basis of model 1 (n = 12490)
  8. Model 8 added education (high school or above, lower than high school) and occupation (manual labor, non-manual labor) on the basis of model 1 (n = 5844)
  9. *Five right knees and four left knees with Kellgren-Lawrence grade 4were excluded from analysis (data from the contralateral knees were retained)
  10. Mg magnesium, N number, CI confidence interval
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Arthritis Research & Therapy

ISSN: 1478-6362

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