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Table 4 Association between serum Mg and knee chondrocalcinosis of study population in the XO Study I (n = 1316)

From: Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis

  Tertiles of serum Mg (mmol/L) P for trend
1 (≤0.89) 2 (0.90–0.95) 3 (≥0.96)
Total
N for knee* 977 793 848 -
 Knee chondrocalcinosis (%) 4.8 3.2 2.0 -
 Model 1 (95% CI) 1.00 (reference) 0.67 (0.34, 1.30) 0.45 (0.21, 0.94) 0.030
 Model 2 (95% CI) 1.00 (reference) 0.68 (0.35, 1.32) 0.45 (0.22, 0.94) 0.046
 Model 3 (95% CI) 1.00 (reference) 0.73 (0.37, 1.47) 0.41 (0.18, 0.93) 0.028
 Model 4 (95% CI) 1.00 (reference) 0.71 (0.35, 1.41) 0.41 (0.18, 0.91) 0.025
 Model 5 (95% CI) 1.00 (reference) 0.73 (0.37, 1.46) 0.42 (0.19, 0.94) 0.032
 Model 6 (95% CI) 1.00 (reference) 0.71 (0.36, 1.41) 0.40 (0.18, 0.91) 0.024
 Model 7 (95% CI) 1.00 (reference) 0.67 (0.34, 1.30) 0.45 (0.21, 0.94) 0.030
 Model 8 (95% CI) 1.00 (reference) 0.69 (0.35, 1.34) 0.45 (0.21, 0.95) 0.032
 Model 9 (95% CI) 1.00 (reference) 0.71 (0.36, 1.42) 0.43 (0.20, 0.95) 0.020
 Model 10 (95% CI) 1.00 (reference) 0.68 (0.35, 1.33) 0.41 (0.19, 0.88) 0.034
 Model 11 (95% CI) 1.00 (reference) 0.68 (0.35, 1.32) 0.45 (0.21, 0.95) 0.033
 Model 12 (95% CI) 1.00 (reference) 0.65 (0.33, 1.28) 0.46 (0.21, 0.96) 0.036
Male
N for knee* 502 397 380 -
 Knee chondrocalcinosis (%) 3.8 2.5 1.1 -
 Model 1 (95% CI) 1.00 (reference) 0.72 (0.26, 2.01) 0.34 (0.08, 1.37) 0.115
 Model 2 (95% CI) 1.00 (reference) 0.75 (0.28, 2.05) 0.34 (0.08, 1.38) 0.114
 Model 3 (95% CI) 1.00 (reference) 0.81 (0.29, 2.30) 0.39 (0.09, 1.66) 0.195
 Model 4 (95% CI) 1.00 (reference) 0.78 (0.28, 2.21) 0.39 (0.09, 1.62) 0.184
 Model 5 (95% CI) 1.00 (reference) 0.87 (0.31, 2.48) 0.40 (0.10, 1.64) 0.198
 Model 6 (95% CI) 1.00 (reference) 0.84 (0.30, 2.35) 0.39 (0.09, 1.60) 0.183
 Model 7 (95% CI) 1.00 (reference) 0.72 (0.26, 2.00) 0.34 (0.09, 1.37) 0.117
 Model 8 (95% CI) 1.00 (reference) 0.65 (0.19, 2.25) 0.47 (0.11, 1.88) 0.254
 Model 9 (95% CI) 1.00 (reference) 0.81 (0.27, 2.42) 0.21 (0.04, 1.08) 0.077
 Model 10 (95% CI) 1.00 (reference) 0.72 (0.26, 2.00) 0.17 (0.04, 0.83) 0.024
 Model 11 (95% CI) 1.00 (reference) 0.63 (0.23, 1.74) 0.32 (0.08, 1.32) 0.094
 Model 12 (95% CI) 1.00 (reference) 0.67 (0.24, 1.93) 0.34 (0.08, 1.38) 0.116
Female
N for knee* 475 396 468 -
 Knee chondrocalcinosis (%) 5.9 3.8 2.8 -
 Model 1 (95% CI) 1.00 (reference) 0.64 (0.27, 1.52) 0.50 (0.20, 1.23) 0.128
 Model 2 (95% CI) 1.00 (reference) 0.65 (0.27, 1.55) 0.50 (0.20, 1.24) 0.130
 Model 3 (95% CI) 1.00 (reference) 0.66 (0.27, 1.65) 0.40 (0.15, 1.10) 0.069
 Model 4 (95% CI) 1.00 (reference) 0.62 (0.25, 1.54) 0.40 (0.14, 1.09) 0.067
 Model 5 (95% CI) 1.00 (reference) 0.66 (0.26, 1.63) 0.42 (0.15, 1.17) 0.090
 Model 6 (95% CI) 1.00 (reference) 0.63 (0.25, 1.58) 0.41 (0.15, 1.10) 0.071
 Model 7 (95% CI) 1.00 (reference) 0.64 (0.27, 1.53) 0.50 (0.20, 1.23) 0.126
 Model 8 (95% CI) 1.00 (reference) 0.66 (0.27, 1.59) 0.50 (0.20, 1.23) 0.129
 Model 9 (95% CI) 1.00 (reference) 0.66 (0.27, 1.59) 0.53 (0.21, 1.33) 0.174
 Model 10 (95% CI) 1.00 (reference) 0.66 (0.27, 1.60) 0.53 (0.21, 1.32) 0.171
 Model 11 (95% CI) 1.00 (reference) 0.68 (0.29, 1.64) 0.52 (0.21, 1.28) 0.149
 Model 12 (95% CI) 1.00 (reference) 0.63 (0.26, 1.50) 0.48 (0.19, 1.21) 0.116
  1. Model 1 included age (50–59, 60–69, ≥70 years), body mass index (BMI) (<25, ≥25 kg/m2) and sex (age and BMI for the sex subgroup) (n = 1316)
  2. Model 2 added knee injury on the basis of model 1 (n = 1316)
  3. Model 3 added serum parathyroid hormone (tertiles) on the basis of model 1 (n = 1250)
  4. Model 4 added serum iron (tertiles) on the basis of model 1 (n = 1250)
  5. Model 5 added serum total iron binding capacity (tertiles) on the basis of model 1 (n = 1241)
  6. Model 6 added serum unsaturated iron binding capacity (tertiles) on the basis of model 1 (n = 1241)
  7. Model 7 added serum calcium (tertiles) on the basis of model 1 (n = 1316)
  8. Model 8 added serum 25(OH)D (tertiles) on the basis of model 1 (n = 1306)
  9. Model 9 added serum zinc (tertiles) on the basis of model 1 (n = 1292)
  10. Model 10 added serum copper (tertiles) on the basis of model 1 (n = 1292)
  11. Model 11 added serum phosphorus (tertiles) on the basis of model 1 (n = 1316)
  12. Model 12 added education (educated, non-educated) and occupation (farmer, non-farmer) on the basis of model 1 (n = 1316)
  13. *Six right knees and eight left knees with Kellgren-Lawrence grade 4 were excluded from analysis (data from the contralateral knees were retained)
  14. Mg magnesium, CI confidence interval