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Table 4 Association between serum Mg and knee chondrocalcinosis of study population in the XO Study I (n = 1316)

From: Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis

 

Tertiles of serum Mg (mmol/L)

P for trend

1 (≤0.89)

2 (0.90–0.95)

3 (≥0.96)

Total

  N for knee*

977

793

848

-

 Knee chondrocalcinosis (%)

4.8

3.2

2.0

-

 Model 1 (95% CI)

1.00 (reference)

0.67 (0.34, 1.30)

0.45 (0.21, 0.94)

0.030

 Model 2 (95% CI)

1.00 (reference)

0.68 (0.35, 1.32)

0.45 (0.22, 0.94)

0.046

 Model 3 (95% CI)

1.00 (reference)

0.73 (0.37, 1.47)

0.41 (0.18, 0.93)

0.028

 Model 4 (95% CI)

1.00 (reference)

0.71 (0.35, 1.41)

0.41 (0.18, 0.91)

0.025

 Model 5 (95% CI)

1.00 (reference)

0.73 (0.37, 1.46)

0.42 (0.19, 0.94)

0.032

 Model 6 (95% CI)

1.00 (reference)

0.71 (0.36, 1.41)

0.40 (0.18, 0.91)

0.024

 Model 7 (95% CI)

1.00 (reference)

0.67 (0.34, 1.30)

0.45 (0.21, 0.94)

0.030

 Model 8 (95% CI)

1.00 (reference)

0.69 (0.35, 1.34)

0.45 (0.21, 0.95)

0.032

 Model 9 (95% CI)

1.00 (reference)

0.71 (0.36, 1.42)

0.43 (0.20, 0.95)

0.020

 Model 10 (95% CI)

1.00 (reference)

0.68 (0.35, 1.33)

0.41 (0.19, 0.88)

0.034

 Model 11 (95% CI)

1.00 (reference)

0.68 (0.35, 1.32)

0.45 (0.21, 0.95)

0.033

 Model 12 (95% CI)

1.00 (reference)

0.65 (0.33, 1.28)

0.46 (0.21, 0.96)

0.036

Male

  N for knee*

502

397

380

-

 Knee chondrocalcinosis (%)

3.8

2.5

1.1

-

 Model 1 (95% CI)

1.00 (reference)

0.72 (0.26, 2.01)

0.34 (0.08, 1.37)

0.115

 Model 2 (95% CI)

1.00 (reference)

0.75 (0.28, 2.05)

0.34 (0.08, 1.38)

0.114

 Model 3 (95% CI)

1.00 (reference)

0.81 (0.29, 2.30)

0.39 (0.09, 1.66)

0.195

 Model 4 (95% CI)

1.00 (reference)

0.78 (0.28, 2.21)

0.39 (0.09, 1.62)

0.184

 Model 5 (95% CI)

1.00 (reference)

0.87 (0.31, 2.48)

0.40 (0.10, 1.64)

0.198

 Model 6 (95% CI)

1.00 (reference)

0.84 (0.30, 2.35)

0.39 (0.09, 1.60)

0.183

 Model 7 (95% CI)

1.00 (reference)

0.72 (0.26, 2.00)

0.34 (0.09, 1.37)

0.117

 Model 8 (95% CI)

1.00 (reference)

0.65 (0.19, 2.25)

0.47 (0.11, 1.88)

0.254

 Model 9 (95% CI)

1.00 (reference)

0.81 (0.27, 2.42)

0.21 (0.04, 1.08)

0.077

 Model 10 (95% CI)

1.00 (reference)

0.72 (0.26, 2.00)

0.17 (0.04, 0.83)

0.024

 Model 11 (95% CI)

1.00 (reference)

0.63 (0.23, 1.74)

0.32 (0.08, 1.32)

0.094

 Model 12 (95% CI)

1.00 (reference)

0.67 (0.24, 1.93)

0.34 (0.08, 1.38)

0.116

Female

  N for knee*

475

396

468

-

 Knee chondrocalcinosis (%)

5.9

3.8

2.8

-

 Model 1 (95% CI)

1.00 (reference)

0.64 (0.27, 1.52)

0.50 (0.20, 1.23)

0.128

 Model 2 (95% CI)

1.00 (reference)

0.65 (0.27, 1.55)

0.50 (0.20, 1.24)

0.130

 Model 3 (95% CI)

1.00 (reference)

0.66 (0.27, 1.65)

0.40 (0.15, 1.10)

0.069

 Model 4 (95% CI)

1.00 (reference)

0.62 (0.25, 1.54)

0.40 (0.14, 1.09)

0.067

 Model 5 (95% CI)

1.00 (reference)

0.66 (0.26, 1.63)

0.42 (0.15, 1.17)

0.090

 Model 6 (95% CI)

1.00 (reference)

0.63 (0.25, 1.58)

0.41 (0.15, 1.10)

0.071

 Model 7 (95% CI)

1.00 (reference)

0.64 (0.27, 1.53)

0.50 (0.20, 1.23)

0.126

 Model 8 (95% CI)

1.00 (reference)

0.66 (0.27, 1.59)

0.50 (0.20, 1.23)

0.129

 Model 9 (95% CI)

1.00 (reference)

0.66 (0.27, 1.59)

0.53 (0.21, 1.33)

0.174

 Model 10 (95% CI)

1.00 (reference)

0.66 (0.27, 1.60)

0.53 (0.21, 1.32)

0.171

 Model 11 (95% CI)

1.00 (reference)

0.68 (0.29, 1.64)

0.52 (0.21, 1.28)

0.149

 Model 12 (95% CI)

1.00 (reference)

0.63 (0.26, 1.50)

0.48 (0.19, 1.21)

0.116

  1. Model 1 included age (50–59, 60–69, ≥70 years), body mass index (BMI) (<25, ≥25 kg/m2) and sex (age and BMI for the sex subgroup) (n = 1316)
  2. Model 2 added knee injury on the basis of model 1 (n = 1316)
  3. Model 3 added serum parathyroid hormone (tertiles) on the basis of model 1 (n = 1250)
  4. Model 4 added serum iron (tertiles) on the basis of model 1 (n = 1250)
  5. Model 5 added serum total iron binding capacity (tertiles) on the basis of model 1 (n = 1241)
  6. Model 6 added serum unsaturated iron binding capacity (tertiles) on the basis of model 1 (n = 1241)
  7. Model 7 added serum calcium (tertiles) on the basis of model 1 (n = 1316)
  8. Model 8 added serum 25(OH)D (tertiles) on the basis of model 1 (n = 1306)
  9. Model 9 added serum zinc (tertiles) on the basis of model 1 (n = 1292)
  10. Model 10 added serum copper (tertiles) on the basis of model 1 (n = 1292)
  11. Model 11 added serum phosphorus (tertiles) on the basis of model 1 (n = 1316)
  12. Model 12 added education (educated, non-educated) and occupation (farmer, non-farmer) on the basis of model 1 (n = 1316)
  13. *Six right knees and eight left knees with Kellgren-Lawrence grade 4 were excluded from analysis (data from the contralateral knees were retained)
  14. Mg magnesium, CI confidence interval
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Arthritis Research & Therapy

ISSN: 1478-6362

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