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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

Fig. 2

Abatacept treatment reduces the development of anti-citrullinated protein antibodies (anti-CarP) antibodies and affects the severity of collagen-induced arthritis in rhesus monkeys. a Anti-CarP IgG antibodies were measured by enzyme-linked immunosorbent assay in rhesus monkeys treated with no medication (n = 10), abatacept (n = 7) or Roactemra (n = 7). The highest anti-CarP antibody level for each monkey is shown. Timelines for the anti-CarP antibodies over time are shown for no treatment (b), abatacept (c) and Roactemra (d). e The clinical score is shown in rhesus monkeys treated with no medication (n = 10), abatacept (n = 7) or Roactemra (n = 7). The highest clinical score for each monkey is shown. Timelines for the clinical score over time are shown for no treatment (f), abatacept (g) and Roactemra (h). Day 0 is the time point of immunization with collagen. The data in e-h were presented before in two separate studies [22, 23] and are shown here as comparison. AU/ml, arbitrary units per millilitre

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