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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway

Fig. 3

In Tyrode’s buffer, the complement system was activated by AAV-plasma stimulated platelets. a Generation of C3a by activated platelets. b Generation of C5a by activated platelets. c Generation of sC5b-9 by activated platelets. d Generation of sC4d by activated platelets. e Deposition of C3c on activated platelets. f Deposition of C5b-9 on activated platelets. ****p < 0.0001, compared with the vehicle group (unpaired t test)

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Arthritis Research & Therapy

ISSN: 1478-6362

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