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Table 2 Fold change expression of microRNAs

From: Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects

miRNA

RA vs HC

FDR vs HC

FDR vs RA

P Value

Fold change

Rank

P Value

Fold change

P Value

Fold change

hsa-miR-103a-3p

0.0064

3.96

1

0.0238

7.68

0.1223

1.97

hsa-miR-155

0.0002

2.47

2

0.0115

1.98

0.3627

−1.25

hsa-miR-29b

0.0648

1.91

3

0.8636

−1.55

0.0754

−2.96

hsa-miR-132

0.0016

1.90

4

0.0687

1.37

0.2530

−1.39

hsa-miR-26b-3p

0.0010

1.88

5

0.0024

2.28

0.2530

1.21

hsa-miR-152

0.0038

1.83

6

0.1309

1.97

0.4981

1.08

hsa-miR-19a

0.0732

1.73

7

0.0205

1.55

0.9662

−1.11

hsa-Let-7a

0.0569

1.73

7

0.2086

1.17

0.2358

−1.47

hsa-miR-19b

0.0260

1.67

9

0.1169

1.34

0.4091

−1.24

hsa-miR-146a-5p

0.0083

1.54

10

0.0031

1.99

0.3408

1.29

hsa-miR-451

0.0076

1.53

11

0.0127

1.56

0.7031

1.02

RNU44

0.0120

1.52

12

0.0162

1.30

0.9157

−1.17

hsa-miR-125a-5p

0.0272

1.30

13

0.0553

1.50

0.7508

1.15

hsa-miR-222

0.0796

1.29

14

0.2154

1.20

0.4587

−1.07

hsa-miR-107

0.0576

1.28

15

0.2481

−1.02

0.4587

−1.31

hsa-miR-29c

0.2428

1.28

16

0.1457

1.11

0.8159

−1.15

hsa-Let-7e

0.0502

1.27

17

0.5837

−1.20

0.0987

−1.53

hsa-miR-21

0.0261

1.24

18

0.0924

1.22

0.7832

−1.16

hsa-miR-223

0.0115

1.22

19

0.5487

1.03

0.5115

−1.82

hsa-miR-26b-5p

0.1191

1.21

20

0.6744

−1.45

0.0277

−1.76

hsa-miR-323-3p

0.1123

1.17

21

0.2033

1.12

0.9831

−1.04

hsa-miR-26a

0.1849

1.14

22

0.1159

1.33

0.8822

1.16

hsa-miR-29a

0.1031

1.14

23

0.6174

−1.29

0.1124

1.46

hsa-miR-15a

0.5594

1.11

24

0.8292

−1.56

0.1223

−1.72

hsa-miR-150

0.6104

1.10

25

0.41

1.20

0.7669

1.09

hsa-miR-34a*

0.1065

1.06

26

0.0495

−1.84

0.0262

−1.94

hsa-miR-221

0.1842

1.06

27

0.9914

−1.37

0.2356

−1.45

hsa-miR-24

0.2956

−1.05

28

0.8651

1.03

0.9831

1.04

hsa-miR-18a

0.7615

−1.07

29

0.7639

−1.85

0.1124

−1.72

U6

0.8069

−1.11

30

0.0001

−1.59

0.0625

−1.43

hsa-miR-125a-3p

0.1654

−1.20

31

0.6178

−1.10

0.4847

1.10

hsa-miR-16

0.9950

−3.94

32

0.8276

−1.24

0.2802

−1.23

hsa-miR-346

0.0001

−8.70

33

0.0001

−20.00

0.0338

−2.32

  1. Abbreviations: FDR First-degree relative, HC Healthy control subjects, miRNA or miR MicroRNA, RA Rheumatoid arthritis
  2. miRNA profiling was analyzed in the whole blood total RNA samples obtained from HC, patients with RA, and FDRs using TaqMan probes. P values were obtained using the Mann-Whitney U test, and median fold change values were used to classify miRNAs rankwise. Columns highlighted in bold represent miRNAs that show significant differential expression after Benjamini-Hochberg correction for multiple comparison analyses (Q < 0.04). RA vs HC indicates miRNA expression in patients with RA compared with HCs. FDR vs HC indicates miRNA expression in FDRs compared with HCs. FDR vs RA indicates miRNA expression in FDRs compared with patients with RA. hsa-miR-34a* represents hsa-miR-34a-3p
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Arthritis Research & Therapy

ISSN: 1478-6362

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