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Table 1 68Ga-DOTA-Siglec-9 uptake in mouse tibiotarsal joints detected using ex vivo gamma counting

From: Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice

 

Tibiotarsal joints

Weeks after infection

Infected

Ceftriaxone-treated infected

Uninfected

2

1.3 ± 0.13

  

3

1.2 ± 0.26

  

4

1.6 ± 0.24

  

5

1.7 ± 0.27a

1.8 ± 0.25a

 

6

0.96 ± 0.11a,b

1.4 ± 0.093

 

7

1.6 ± 0.23a,b

1.1 ± 0.17

1.2 ± 0.067

  1. The results are expressed as the percentage of injected radioactivity dose per gram of tissue (mean ± SD) measured at 30 minutes after injection of gallium-68-labeled Siglec-9 motif containing peptide (68Ga-DOTA-Siglec-9)
  2. a Significant difference in comparison with uninfected mice
  3. b Significant difference in comparison with ceftriaxone-treated infected mice