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Table 3 Discontinuations (several reasons could be given in parallel

From: Experience with etanercept, tocilizumab and interleukin-1 inhibitors in systemic onset juvenile idiopathic arthritis patients from the BIKER registry

 

Etanercept

Tocilizumab

Interleukin-1 inhibitor

Discontinuations

77 (53.8%)

28 (39.4%)

28 (46.7%)

Inefficacy

62 (43.4%)

6 (8.5%)

13 (21.7%)

Intolerance

5 (3.5%)

14 (19.7%)

1 (1.7)

Remission

0

18 (25.4%)

11 (18.3)

Othersa

15 (10.5%)

3 (4.2%)

3 (5.0%)

  1. aOther reasons: in the etanercept cohort, patient’s/parent’s wish (n = 6); no further visits by the patient (n = 2), treatment with approved biologic available (n = 2), no restart after an adverse event although it disappeared (n = 2), reason not reported (n = 3); in patients on anakinra, a patient was admitted to a clinical trial (n = 1), reason not reported (n = 2); in patients on tocilizumab, reason not reported (n = 3)