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Table 1 Demographic and clinical characteristics of participants in two cohorts

From: Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

 

Training cohort

Validation cohort

RA (before 1 May 2016)

Control (before 1 May 2016)

RA (after 16 May 2016)

non-RA (after 16 May 2016)

Sex (female/male), n

80/18

50/53

174/43

187/168

Age (years)

58 (27, 85)

49 (19, 86)

59 (15, 84)

48 (13, 94)

Symptom duration (years)

10 (0.01, 50)

NA

5 (0.01, 50)

4 (0.01, 50)

CRP (mg/L)

22 (0.6, 331)

NA

18.6 (0.16, 339)

8.0 (0.16, 436)

ESR (mm/h)

44 (2, 140)

NA

42 (2, 134)

24 (2, 120)

ACPA positive, n (%)

71 (72)

NA

147(68)

12 (3)

RF positive, n (%)

65 (66)

NA

136 (63)

63 (18)

Serum CTGF (pg/mL)

293.9 (7.87, 1285)

30 (0.16, 171.3)

289.2 (1.82, 2351)

22.45 (0.12, 541)

Synovial fluid CTGF (pg/mL)

534 (1.55, 2574)

23.87 (2.65, 166.8)

NA

NA

  1. Values are expressed as median (minimum, maximum) unless state otherwise
  2. Abbreviations: RA rheumatoid arthritis, NA not applicable, CRP C-reactive protein, ESR erythrocyte sedimentation rate, ACPA antibodies directed against citrullinated peptides, RF rheumatoid factor, CTGF connective tissue growth factor