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Table 2 Evaluation of the diagnostic experiment using CTGF in the validation cohort

From: Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Testsa Sensitivity Specificity Positive likelihood ratio Negative likelihood ratio Positive predictive value Negative predictive value Youden index
CTGF test in all participantsb 0.82 0.91 5.74 0.12 0.85 0.90 0.73
CTGF test in ACPA-negative participantsc 0.76 0.91 1.71 0.05 0.63 0.95 0.67
CTGF test in RF-negative participantsd 0.79 0.91 2.46 0.06 0.71 0.94 0.70
  1. CTGF connective tissue growth factor, ACPA anti-citrullinated protein antibodies, RF rheumatoid factor
  2. aDiagnostic experiments using CTGF with the cutoff 88.66 pg/mL, which was obtained from the training cohort data as described previously
  3. bEvaluation of the CTGF test in all participants in the validation cohort
  4. cEvaluation of the CTGF test in participants in the validation cohort who were ACPA-negative
  5. dEvaluation of the CTGF test in participants in the validation cohort who were RF-negative