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Table 1 Associations between miRNAs expression levels in T cells and clinical parameters in rheumatoid arthritis patients

From: The role of aberrant expression of T cell miRNAs affected by TNF-α in the immunopathogenesis of rheumatoid arthritis

miRNA Age (per 10 years Sex (male/female) CRP (mg/dL) ACPAs (per 10 IU/mL) Positivity of RF (yes/no) Sulfalsalazine usage (yes/no) MTX dosage (mg/week) Leflunomide usage (yes/no) Steroid dosage equivalent to perdnisolone (mg/day) Biologic agenta usage (yes/no)
miR-139-3p 0.07 (0.816) –0.35 (0.732) –0.26 (0.460) -0.03 (0.373) –1.73 (0.031) –0.50 (0.683) 0.06 (0.581) 0.51 (0.508) 0.50 (0.054) 2.02 (0.007)
miR-204 0.15 (0.615) –1.36 (0.128) –0.33 (0.285) -0.04 (0.152) –0.63 (0.385) –1.27 (0.233) –0.06 (0.484) 0.26 (0.700) 0.09 (0.707) 2.04 (0.002)
miR-214 –0.26 (0.344) –0.05 (0.949) –0.72 (0.010) -0.01 (0.515) –0.96 (0.158) –1.56 (0.116) –0.10 (0.287) 1.02 (0.107) 0.03 (0.900) 1.50 (0.016)
miR-383 –0.03 (0.891) –0.82 (0.309) 0.11 (0.687) 0.02 (0.497) –0.12 (0.854) –2.72 (0.003) –0.22 (0.009) –0.26 (0.672) –0.53 (0.009) 0.41 (0.507)
miR-524-5p –0.39 (0.307) –0.93 (0.435) –0.41 (0.313) 0.00 (0.921) –1.07 (0.266) –1.32 (0.353) –0.07 (0.568) 0.69 (0.447) 0.09 (0.775) 0.63 (0.488)
miR-548d-3p –0.19 (0.494) –0.14 (0.870) –0.45 (0.123) 0.05 (0.051) 0.14 (0.845) –1.66 (0.098) –0.01 (0.880) –0.43 (0.505) 0.02 (0.926) 0.42 (0.524)
miR-760 –0.40 (0.253) 0.29 (0.795) –0.23 (0.553) -0.01 (0.780) –1.08 (0.226) –1.56 (0.234) –0.08 (0.485) 1.73 (0.035) 0.51 (0.074) 2.32 (0.004)
miR-877 –0.48 (0.235) –0.27 (0.833) –0.04 (0.922) -0.02 (0.554) 0.05 (0.965) –0.32 (0.830) –0.08 (0.563) 1.28 (0.175) 0.36 (0.266) 1.30 (0.174)
  1. Values shown are correlation coefficients and (p values) from simple linear regression, and those in bold represent p < 0.05
  2. ACPAs anti-citrullinated protein antibodies, CRP C-reactive protein, miRNA microRNAs, MTX methotrexate, RF rheumatoid factor
  3. aBiologic agent including: tumor necrosis factor antagonists, abatacept, and tocilizumab
  4. Values shown are correlation coefficients and (p values) from simple linear regression, and those in bold represent p < 0.05