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Table 2 Adjusted associations between miRNAs expression levels in T cells and parameters in rheumatoid arthritis patients

From: The role of aberrant expression of T cell miRNAs affected by TNF-α in the immunopathogenesis of rheumatoid arthritis

miRNA Age (per 10 years Sex (male/female) CRP (mg/dL) ACPAs (per 10 IU/mL) Positivity of RF (yes/no) Sulfasalazine usage (yes/no) MTX dosage (mg/week) Leflunomide usage (yes/no) Steroid dosage equivalent to perdnisolone (mg/day) Biologic agenta usage (yes/no)
miR-139-3p 1.03 (0.68–1.56) 0.78 (0.21–2.84) 0.33 (0.120.94) 1.37 (0.98–1.92) 2.84 (1.067.64)
miR-204 0.83 (0.59–1.16) 0.27 (0.090.78) 4.48 (2.029.90)
miR-214 0.88 (0.62–1.24) 0.60 (0.20–1.80) 0.65 (0.450.94) 2.44 (1.085.48)
miR-383 1.08 (0.77–1.52) 0.71 (0.24–2.09) 0.33 (0.08–1.36) 0.93 (0.82–1.05) 0.81 (0.60–1.10)
miR-548d-3p 0.80 (0.52–1.22) 0.55 (0.14–2.16) 0.62 (0.13–2.96)
miR-760 0.72 (0.46–1.11) 0.97 (0.25–3.81) 2.54 (0.94–6.90) 1.35 (0.95–1.93) 3.66 (1.3110.22)
  1. Values shown are fold change (95% confidence interval) calculated using multiple linear regression analysis, and those in bold represent p < 0.05
  2. ACPAs anti-citrullinated protein antibodies, CRP C-reactive protein, miRNA microRNAs, MTX methotrexate, RF rheumatoid factor
  3. aBiologic agent including: tumor necrosis factor antagonists, abatacept, and tocilizumab