Table 2 Adjusted associations between miRNAs expression levels in T cells and parameters in rheumatoid arthritis patients
miRNA | Age (per 10 years | Sex (male/female) | CRP (mg/dL) | ACPAs (per 10 IU/mL) | Positivity of RF (yes/no) | Sulfasalazine usage (yes/no) | MTX dosage (mg/week) | Leflunomide usage (yes/no) | Steroid dosage equivalent to perdnisolone (mg/day) | Biologic agenta usage (yes/no) |
|---|---|---|---|---|---|---|---|---|---|---|
miR-139-3p | 1.03 (0.68–1.56) | 0.78 (0.21–2.84) | – | – | 0.33 (0.12–0.94) | – | – | – | 1.37 (0.98–1.92) | 2.84 (1.06–7.64) |
miR-204 | 0.83 (0.59–1.16) | 0.27 (0.09–0.78) | – | – | – | – | – | – | – | 4.48 (2.02–9.90) |
miR-214 | 0.88 (0.62–1.24) | 0.60 (0.20–1.80) | 0.65 (0.45–0.94) | – | – | – | – | – | – | 2.44 (1.08–5.48) |
miR-383 | 1.08 (0.77–1.52) | 0.71 (0.24–2.09) | – | – | – | 0.33 (0.08–1.36) | 0.93 (0.82–1.05) | – | 0.81 (0.60–1.10) | – |
miR-548d-3p | 0.80 (0.52–1.22) | 0.55 (0.14–2.16) | – | 0.62 (0.13–2.96) | – | – | – | – | – | – |
miR-760 | 0.72 (0.46–1.11) | 0.97 (0.25–3.81) | – | – | – | – | – | 2.54 (0.94–6.90) | 1.35 (0.95–1.93) | 3.66 (1.31–10.22) |