Time since first CZP dose | IR/100 PY (95% CI)a | |||||
---|---|---|---|---|---|---|
Without systemic glucocorticoid use | With systemic glucocorticoid use | |||||
AACI = 0 | AACI = 1 | AACI ≥ 2 | AACI = 0 | AACI = 1 | AACI ≥ 2 | |
RCT CZP | ||||||
Patients, n | 158 | 250 | 110 | 271 | 295 | 140 |
3 months | 2.6 (0.1–14.5) | 4.9 (1.0–14.3) | 7.8 (1.0–28.2) | 4.5 (0.9–13.3) | 9.8 (3.9–20.2) | 11.9 (3.2–30.5) |
6 months | 1.4 (0.0–8.0) | 3.7 (1.0–9.6) | 6.8 (1.4–19.9) | 5.1 (1.9–11.1) | 8.6 (4.3–15.4) | 12.1 (4.9–25.0) |
1 year | 1.0 (0.0–5.3) | 3.2 (1.0–7.4) | 6.2 (1.7–15.9) | 4.6 (2.0–9.1) | 6.2 (3.2–10.9) | 12.1 (5.8–22.2) |
All CZP | ||||||
Patients, n | 205 | 302 | 130 | 325 | 379 | 165 |
3 months | 2.0 (0.1–11.1) | 4.1 (0.8–11.9) | 6.6 (0.8–23.7) | 3.8 (0.8–11.1) | 8.7 (3.8–17.1) | 12.6 (4.1–29.4) |
6 months | 4.1 (1.1–10.5) | 2.8 (0.8–7.1) | 5.1 (1.0–14.8) | 4.5 (1.8–9.3) | 7.8 (4.3–13.1) | 11.7 (5.4–22.2) |
1 year | 4.8 (2.2–9.1) | 2.2 (0.8–4.7) | 5.3 (2.0–11.6) | 4.3 (2.3–7.4) | 8.0 (5.3–11.7) | 12.6 (7.5–20.0) |
2 years | 3.4 (1.8–6.0) | 2.7 (1.5–4.5) | 8.9 (5.3–14.0) | 3.9 (2.5–5.9) | 6.0 (4.3–8.3) | 8.4 (5.2–12.8) |