Skip to main content

Advertisement

Table 2 Systemic Lupus Erythematosus Disease Activity Index-qualifying symptoms and C4d levels at higher disease activity in the cross-sectional study (n = 98)

From: Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus

  Higher disease activity Lower disease activity
  Feature present Feature absent   
Clinical features No. of subjects C4d (mg/L) No. of subjects C4d (mg/L) p Value No. of subjects
Seizure 2 0.56 (0–1.12) 96 0.49 (0.09–1.32) 0
Psychosis 0 98 0.49 (0.08–1.31) 0
Organic brain syndrome 0 98 0.49 (0.08–1.31) 0
Visual disturbance 7 0.53 (0.35–0.88) 91 0.45 (0.05–1.32) 0.658 0
Cranial nerve disorder 0 98 0.49 (0.08–1.31) 0
Lupus headache 2 0.39 (0–0.77) 96 0.49 (0.09–1.32) 0
Cerebrovascular accident 2 0 96 0.51 (0.10–1.32) 0
Vasculitis 12 0.73 (0.33–1.44) 86 0.46 (0.05–1.16) 0.342 0
Arthritis 29 0.15 (0.001–1.03) 69 0.65 (0.21–1.33) 0.033 1
Myositis 1 0.19 (0.19–0.19) 97 0.51 (0.07–1.31) 0
Kidney involvement (urinary cast, hematuria, proteinuria, or pyuria) 34 0.89 (0.44–1.56) 64 0.34 (0 –1.12) 0.003 1
Rash 30 0.45 (0.10–1.15) 68 0.52 (0.05 –1.38) 0.745 4
Alopecia 7 0.33 (0.03–0.76) 91 0.51 (0.09 –1.32) 0.365 1
Oral ulcers 7 0.40 (0.11–1.24) 91 0.51 (0.05 –1.32) 0.868 0
Pleurisy 13 0.88 (0.34–2.16) 85 0.44 (0.05 –1.19) 0.172 0
Pericarditis 7 1.07 (0.12–2.85) 91 0.45 (0.05 –1.24) 0.237 0
Low complement (C3 or C4) 54 0.87 (0.35–1.46) 44 0.17 (0–0.99) 0.001 40
Anti-DNA antibodies 46 1.02 (0.49–1.51) 52 0.16 (0–0.73) <0.0001 24
Fever 6 1.18 (0.76–2.82) 92 0.45 (0.05–1.26) 0.069 0
Thrombocytopenia 3 0.40 (0.18–1.51) 95 0.45 (0.04–1.12) 2
Leukopenia 10 0.47 (0.22–1.53) 88 0.44 (0.03–1.12) 0.49 6
  1. C4d levels are presented as median (25–75% quantile), and significance was calculated using the Mann-Whitney U test. Significant p Values are highlighted in bold. C4d levels were calculated only when more than five patients had the particular symptom at higher disease activity