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Table 4 Odds ratios for the presence of high-grade cartilage damage progression by Δdi-C6S, KS levels, C6S/C4S

From: Prediction of progression of damage to articular cartilage 2 years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study

Variables   Unadjusted OR Adjusted OR
  (95% CI) p value   (95% CI) p value
Δdi-C6S ≤55.7 1 Reference   1 Reference  
(nmol/ml) >55.7 0.179 (0.051–0.638) 0.008 0.231 (0.061–0.879) 0.032
Δdi-C4S ≤19.0 1 Reference   1 Reference  
(nmol/ml) >19.0 0.081 (0.010–0.668) 0.020 0.081 (0.008–0.763) 0.028
KS ≤10.6 1 Reference   1 Reference  
(μg/ml) >10.6 0.154 (0.042–0.568) 0.005 0.114 (0.024–0.529) 0.006
C6S/C4S ≤4.6 1 Reference   1 Reference  
  >4.6 0.105 (0.013–0.869) 0.037 0.060 (0.005–0.737) 0.028
  1. All independent variables were dichotomized using the cut-off points calculated by ROC analysis and tested in a binary manner. The adjusted model included variables (age, duration from injury to ACL reconstruction, sex, and the number of high-grade cartilage lesions [Outerbridge grades III and IV]) at baseline. P < 0.05 was considered statistically significant