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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis

Fig. 2

Histopathological and macrophage analysis in the synovial membrane (SM). a-d Representative sections of SM stained with hematoxylin-eosin or e-h stained with a monoclonal anti-rabbit macrophage antibody (RAM11) from Control rabbit (a and e); rabbit fed with a high-fat diet (HFD) (b and f); osteoarthritic (OA) rabbit (c and g); and OA rabbit fed with a HFD (OA-HFD) (d and h). a-d Scale bar = 100 μm. e-f Scale bar = 100 μm. i Synovitis score quantified as described in “Methods. j Quantification of RAM11-positive area represented as percentage of total area. Data from individual measurements and mean for each group are shown. n = 12–20 SM per group for histopathological analysis; n = 10–16 SM per group for RAM11 analysis

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