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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: VISTA deficiency attenuates antibody-induced arthritis and alters macrophage gene expression in response to simulated immune complexes

Fig. 5

Reduced chemotactic and signal transduction responses to C5a in BMDM cells from V-KO mice. a Chemotactic response to C5a by BMDM cells cultured from wild-type (WT) mice (open bars) and V-KO (KO) mice (black bars). b Western blot analysis of total and phosphorylated AKT (AKT pathway activation) in WT and V-KO BMDMs stimulated with 50 ng/ml C5a for indicated time (minutes). c Western blot analysis for total and phosphorylated ERK (MAPK pathway activation) in WT and V-KO BMDMs stimulated with 50 ng/ml C5a for indicated time (minutes). Student t test (two-tailed): **p < 0.025; *p < 0.05. LPS lipopolysaccharide

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