Is the relationship between increased knee muscle strength and improved physical function following exercise dependent on baseline physical function status?

Hall, Michelle; Hinman, Rana S.; van der Esch, Martin; van der Leeden, Marike; Kasza, Jessica; Wrigley, Tim V.; Metcalf, Ben R.; Dobson, Fiona; Bennell, Kim L.

doi:10.1186/s13075-017-1477-8

Table 3 Linear relationships between 12-week change in strength-related measures (independent variable) and 12-week change in WOMAC function (dependent variable) for the entire cohort and according to physical dysfunction severity at baseline using imputed data

From: Is the relationship between increased knee muscle strength and improved physical function following exercise dependent on baseline physical function status?

		Univariable analysis			Multivariable analysis^a			Multivariable analysis^b			Multivariable analysis^c
		Regression coefficient (95% CI)	p value	Adj. R ²	Regression coefficient (95% CI)	p value	Adj. R ²	Regression coefficient (95% CI)	p value	Adj. R ²	Regression coefficient (95% CI)	p value	Adj. R ²
Entire cohort
Δ Knee extensor strength (Nm/kg)		−17.3 (−29.5 to −5.2)	0.01	0.09	−17.7 (−30.0 to −5.3)	0.01	0.08	−17.9 (−30.5 to −5.3)	0.01	0.06	−17.2 (−29.4 to −4.9)	0.01	0.10
Δ Knee flexor strength (Nm/kg)		−19.6 (−44.4 to 5.3)	0.12	0.03	−19.0 (−44.0 to 6.0)	0.13	0.05	−19.3 (−44.6 to 6.0)	0.13	0.00	−22.0 (−46.4 to 2.5)	0.08	0.06
According to baseline physical dysfunction
Δ Knee extensor strength (Nm/kg)				0.27^d			0.27^d			0.26^d			0.33^d
	Mild	−2.7 (−26.1 to 20.8)	0.82		−1.7 (−25.9 to 22.5)	0.89		−2.2 (−26.7 to 22.2)	0.86		4.8 (−20.2 to 29.8)	0.70
	Moderate	−13.4 (−32.6 to 5.9)	0.17		−13.8 (−32.7 to 5.2)	0.15		−13.4 (−33.3 to 6.4)	0.18		−16.9 (−35.7 to 1.9)	0.08
	Severe	−24.0 (−42.2 to −5.7)	0.01		−24.8 (−43.1 to −6.4)	0.01		−24.9 (−43.1 to −6.5)	0.01		−24.2 (−41.7 to −6.7)	0.01
Δ Knee flexor strength (Nm/kg)				0.22^d			0.21^d			0.20^d			0.27^d
	Mild	0.01 (−34.8 to 35.0)	0.99		−2.8 (−33.2 to 38.8)	0.88		2.20 (−34.4 to 38.8)	0.90		−7.3 (−44.3 to 29.7)	0.69
	Moderate	−13.9 (−45.0 to 17.2)	0.38		−13.8 (−44.5 to 16.8)	0.37		−14.21 (−45.2 to 16.8)	0.36		−10.2 (−39.8 to 19.3)	0.49
	Severe	−42.0 (−99.6 to 15.6)	0.15		−42.7 (−101.3 to 16.0)	0.15		−42.00 (−100.8 to 16.8)	0.16		−47.6 (−100.7 to 5.6)	0.08

Adj. adjusted, CI confidence interval, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index
^aAdjusted for sex, age
^bAdjusted for sex, age, exercise group, baseline strength
^cAdjusted for sex, age, exercise group, baseline strength, change in pain (visual analogue scale)
^dAdjusted R ² value for the entire model including all terms

Back to article page

ISSN: 1478-6362

Contact us

General enquiries: journalsubmissions@springernature.com

Arthritis Research & Therapy

Contact us