Fig. 1
Continuous and categorical baseline predictors of disease activity score based on 28 joints (DAS28) (a), Simplified Disease Activity Index (SDAI) (b), and Clinical Disease Activity Index (CDAI) (c) remission using univariate logistic regression (unadjusted). If the 95% CI does not contain the value 1.0, the predictor is statistically significant at α = 0.5. Non-significant predictors, black; significant predictors, gray. For continuous predictors with odds ratios >1, higher values are associated with a greater likelihood of remission. For numeric categorical predictors with odds ratios >1, higher numeric subgroups are associated a greater likelihood of remission (e.g., patients with body mass index (BMI) 18.5–25 kg/m2 are more likely to achieve DAS28 remission than patients with BMI <18.5 kg/m2); for nominal categorical predictors, the first named subgroup is associated with a greater likelihood of remission (e.g., anti-citrullinated peptide antibody (ACPA) + patients are more likely to achieve DAS28 remission than ACPA- patients). Conversely, for continuous predictors with odds ratios <1, lower values are associated with a greater likelihood of remission. For numeric categorical predictors with odds ratios <1, lower numeric subgroups are associated with a greater likelihood of remission (e.g., patients who are ≤40 years of age are more likely to achieve DAS28 remission than patients who are >40 years of age); for nominal categorical predictors with odds ratios <1, the second named subgroup is associated with a greater likelihood of remission (e.g., patients with erythrocyte sedimentation rate (ESR) levels ≤ upper limit of normal (ULN) are more likely to achieve DAS28 remission than patients with ESR > ULN). BL, baseline; CI, confidence interval; CRP, C-reactive protein; HAQ, Health Assessment Questionnaire; JSN, joint space narrowing: mTSS, modified total Sharp score: PGA, physician global assessment; PtGA patient global assessment; RF, rheumatoid factor. Analyses were adjusted for baseline DAS28, SDAI, and CDAI (respectively). Patients included in the DAS28, SDAI, and CDAI remission models: n = 763, n = 755, and n = 762, respectively. Radiographic variables were excluded from the stepwise analyses because 55 patients did not have radiographic data