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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models

Fig. 1

Atsttrin prevented accelerated OA caused by PGRN deficiency. a Intraarticular injection of Atsttrin protected against articular cartilage loss following the surgically induced DMM model in PGRN–/– mice, assayed by Safranin O staining. b, c Quantification of OARSI score and proteoglycan loss based on Safranin O staining. d Atsttrin-reduced serum level of COMP fragments, assayed by ELISA. Values are mean ± SEM of six mice. *p < 0.05, **p < 0.01 versus PBS-treated group. KO knockout, OARSI Osteoarthritis Research Society International, PBS phosphate-buffered saline, WT wildtype

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