Fig. 4
From: Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models
Atsttrin protects against OA through TNFRs. a Atsttrin protected against degeneration of articular cartilage in WT mice following surgical induction of the ACLT model, but this protection was partially lost in TNFR1–/– mice and almost abolished in TNFR2–/– mice, assayed by Safranin O staining. n = 6 for each group. b, c OARSI score and proteoglycan loss based on Safranin O staining. d Atsttrin-decreased COMP fragment level in serum, assayed by ELISA. Values are mean ± SEM of at least three independent experiments. *p < 0.05, **p < 0.01 versus PBS-treated group. COMP cartilage oligomeric matrix protein, NS not significant, OARSI Osteoarthritis Research Society International, PBS phosphate-buffered saline, WT wildtype, TNFR tumor necrosis factor receptor