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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts

Fig. 2

CX3CR1 is involved in CX3CL1-mediated MMP-3 production in OASFs. a, b OSAFs were transfected for 24 h with CX3CR1 siRNA, followed by stimulation with CX3CL1 for 24 h. MMP-3 expression examined using qPCR and ELISA. c-e OASFs were pretreated for 30 min with CX3CR1 mAb followed by stimulation with CX3CL1 for 24 h. MMP-3 expression was examined using qPCR, ELISA and western blot. Results expressed as mean ± SEM (n = 3). *p < 0.05 compared with control; #p < 0.05 compared with CX3CL1-treated group. mAb monoclonal antibody, MMP matrix metalloproteinase, siRNA small interfering RNA

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