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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: The effect of kidney function on the urate lowering effect and safety of increasing allopurinol above doses based on creatinine clearance: a post hoc analysis of a randomized controlled trial

Fig. 3

Deaths and treatment-emergent or worsening laboratory adverse events (AEs): number of individuals with at least one AE over the 24-month study period by kidney function groups in the dose escalation phase (control/DE) and immediate dose escalation (DE/DE) groups. a Deaths. b-e Liver function. f Percentage of participants with increase in creatinine from baseline (solid bars, C/DE; open bars, DE/DE, Common Terminology Criteria for Adverse Events (CTCAE) grade 1. Hatched area indicates CTCAE grade 2). g, h Percentage of participants with > 20% decrease (worsening) (g) or increase (improvement) (h) in creatinine clearance (CrCL) from baseline. GGT, gamma glutamyl transferase; AST aspartate aminotransferase; ALT, alanine transaminase; ALP, alkaline phosphatase

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