Change in serum urate (mg/dl), mean (SE)
|
Baseline to month 12
|
-0.67 (0.67)
|
-0.05 (0.33)
|
-0.25 (0.26)
|
-1.49 (0.47)
|
-2.27 (0.29)
|
-1.06 (0.24)
|
0.04
|
Baseline to month 24
|
-2.23 (0.88)
|
-1.41 (0.36)
|
-1.10 (0.25)
|
-2.47 (0.68)
|
-2.35 (0.28)
|
-0.86 (0.27)
|
0.15
|
Month 12 to month 24
|
-1.42 (0.45)
|
-1.51 (0.41)
|
-0.87 (0.25)
|
-1.20 (0.29)
|
0.01 (0.17)
|
0.34 (0.23)
|
0.82
|
Serum urate <6 mg/dl, %
|
Month 12
|
13%
|
25%
|
49%
|
57%
|
86%
|
86%
|
0.50
|
Month 24
|
57%
|
68%
|
72%
|
71%
|
82%
|
79%
|
0.93
|
Mean (SE) serum urate
|
Baseline
|
8.25 (0.41)
|
7.10 (0.29)
|
6.82 (0.21)
|
8.02 (0.46)
|
7.63 (0.26)
|
6.52 (0.20)
|
<0.001b
|
Month 12
|
7.38 (0.57)
|
7.13 (0.32)
|
6.37 (0.24)
|
5.91 (0.59)
|
5.25 (0.12)
|
5.34 (0.19)
|
0.20
|
Month 24
|
5.93 (0.71)
|
5.72 (0.25)
|
5.62 (0.19)
|
5.21 (0.30)
|
5.27 (0.18)
|
5.61 (0.25)
|
0.46
|
Percentage change in serum urate from baseline, mean (SE)
|
Baseline to month 12
|
-6.2 (7.2)
|
1.6 (4.9)
|
-1.9 (3.4)
|
-20.2 (6.0)
|
-27.5 (2.9)
|
-15.0 (3.5)
|
0.08
|
Baseline to month 24
|
-25.5 (8.5)
|
-16.6 (4.8)
|
-13.9 (3.2)
|
-30.0 (5.8)
|
-29.1 (2.8)
|
-11.8 (4.1)
|
0.14
|
Month 12 to month 24
|
-19.4 (5.4)
|
-17.9 (4.6)
|
-10.1 (3.5)
|
-2.4 (5.4)
|
0.87 (3.2)
|
7.75 (4.6)
|
0.99
|
Percentage with at least one flare in preceding month
|
Baseline
|
50%
|
38.7%
|
56.3%
|
40.0%
|
32.5%
|
42.5%
|
0.17b
|
Month 12
|
37.5%
|
12.5%
|
39%
|
14.3%
|
34.3%
|
32.1%
|
0.10
|
Month 24
|
14.3%
|
13.6%
|
20.5%
|
0.0%
|
15.2%
|
3.4%
|
0.30
|
Allopurinol dose (mg/day) to achieve target SU at month 24, mean (range)
|
262.5 (150–500)
|
389.3 (250–650)
|
439.3 (300–800)
|
350.0 (250–600)
|
396.3 (200–700)
|
491.3 (300–900)
|
0.002b
|
Number of participants requiring >300 mg/day to achieve target SU at month 24
|
1/4 (25%)
|
9/14 (64.3%)
|
20/28 (71.4%)
|
1/5 (20%)
|
16/27 (59.3%)
|
19/23 (82.6%)
|
0.013
|
Percentage of individuals receiving anti-inflammatory prophylaxis
|
Baseline
|
35.7%
|
48.4%
|
52.1%
|
40.0%
|
60.0%
|
57.5%
|
0.30b
|
Month 12
|
37.5%
|
29.2%
|
29.3%
|
71.4%
|
34.3%
|
14.3%
|
0.15
|
Month 24
|
14.3%
|
18.2%
|
15.4%
|
57.1%
|
9.1%
|
10.3%
|
0.16
|
HAQ mean (SE) change
|
Baseline to month 12
|
-0.10 (0.19)
|
0.10 (0.15)
|
-0.14 (0.09)
|
0.47 (0.28)
|
0.06 (0.12)
|
-0.13 (0.11)
|
0.25
|
Baseline to month 24
|
-0.09 (0.21)
|
0.14 (0.11)
|
-0.32 (0.07)
|
-0.19 (0.30)
|
-0.05 (0.11)
|
-0.20 (0.12)
|
0.67
|
Month 12 to month 24
|
0.10 (0.04)
|
-0.09 (0.18)
|
-0.22 (0.08)
|
-0.72 (0.35)
|
-0.05 (0.13)
|
-0.05 (0.11)
|
0.04
|
Pain VAS mean (SE) change
|
Baseline to month 12
|
-0.25 (0.90)
|
1.04 (0.51)
|
-0.02 (0.40)
|
0.43 (0.61)
|
0.17 (0.40)
|
-0.43 (0.54)
|
0.57
|
Baseline to month 24
|
-1.15 (1.3)
|
0.27 (0.62)
|
-1.10 (0.35)
|
-0.50 (1.36)
|
-0.64 (0.37)
|
-1.28 (0.53)
|
0.56
|
Month 12 to month 24
|
-0.71 (0.71)
|
-0.52 (0.84)
|
-1.03 (0.37)
|
-0.60 (0.87)
|
-0.67 (0.34)
|
-0.78 (0.57)
|
0.93
|
SJC mean (SE) change
|
Baseline to month 12
|
-2.88 (1.84)
|
-0.04 (1.05)
|
-0.07 (0.72)
|
0.86 (1.6)
|
-1.17 (0.89)
|
0.17 (0.53)
|
0.19
|
Baseline to month 24
|
-2.14 (1.39)
|
-2.86 (1.65)
|
-1.26 (0.73)
|
-0.67 (0.67)
|
-1.85 (0.93)
|
-0.24 (0.27)
|
0.99
|
Month 12 to month 24
|
1.23 (1.16)
|
-2.91 (2.24)
|
-1.34 (0.98)
|
0 (0)
|
-0.52 (0.42)
|
-0.37 (0.59)
|
0.57
|
TJC mean (SE) change
|
Baseline to month 12
|
2.13 (3.56)
|
0.04 (1.33)
|
-2.83 (1.07)
|
-0.57 (0.62)
|
-1.57 (0.90)
|
1.18 (1.42)
|
0.04
|
Baseline to month 24
|
-2.57 (1.97)
|
-1.73 (1.49)
|
-2.08 (0.88)
|
-0.50 (0.34)
|
-0.42 (1.54)
|
-0.97 (0.50)
|
0.97
|
Month 12 to month 24
|
-5.0 (3.0)
|
-2.57 (1.83)
|
0.65 (0.55)
|
-0.20 (0.20)
|
1.18 (1.32)
|
-1.96 (1.37)
|
0.02
|