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Table 1 Demographics of the longitudinally observed patients, deceased patients and patients lost to follow up (N = 147)

From: Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study

Demographics Longitudinally observed patients (N = 118) Lost to follow up (N = 13) Deceased before re-examination (N = 16)
Age at T1, years, mean (SD) 44 (14) 48 (16) 61 (13)a
Disease duration at T1 years, mean (SD) 10 (8) 11 (9) 11 (7)
Male gender, N (%) 28 (24) 1 (8) 4 (25)
Anti-RNP, U/mL, median (IQR) 92 (19–240) 91 (33–235) 90 (4–196)
Puffy handsb, N (%) 108 (92) 12 (92) 14 (88)
Arthritisb, N (%) 92 (78) 12 (92) 12(75)
Myositisb, N (%) 36 (30) 3 (23) 6 (38)
Pericarditisb, N (%) 11 (9) 2 (15) 6 (38)c
Sclerodactyly, N (%) 33 (28) 6 (46) 5 (31)
Plevritisb, N (%) 14 (12) 3 (23) 4 (25)
Percentage DLCO pred, mean (SD) 75 (19) 75 (14) 66 (16)
Percentage FVC pred, mean (SD) 93 (18) 88 (19) 88 (24)
Interstitial lung disease, N (%) 39 (34) 4 (50) 9 (69)d
  1. T1 time point 1, Anti-RNP anti-ribonucleoprotein, DCLO pred predicted value of gas diffusing capacity of the lung for carbon monoxide, FVC pred predicted value of forced vital capacity
  2. aSignificant mean age difference between the deceased patients compared to the longitudinally observed patients of 17 years (95% CI 8–26, P < .001) and compared to the patients that were lost to follow up: 13 years (95% CI 1–26, P = .033)
  3. bEver present at T1
  4. cSignificantly higher prevalence of pericarditis (P = .001) in the deceased patients compared to the longitudinally observed patients
  5. dSignificantly higher prevalence of interstitial lung disease (P = .038) in the deceased patients compared to the longitudinally observed patients