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Table 2 Clinical parameters of patients with stable MCTD phenotype and diagnostic converters at time point 1

From: Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study

Demographics Stable MCTD phenotype
N = 104
Diagnostic converters
N = 14
Age, years, mean (SD) 43 (14) 45 (13)
Disease duration years, mean (SD) 10 (9) 9 (7)
Male gender, N (%) 27 (26) 1 (7)
Alarcon-Segovia’s criteria 95 (91) 13 (93)
Kasukawa’s criteria 89 (86) 12 (86)
Sharp’s criteria 101 (97) 13 (93)
Interstitial lung disease, N (%) 36 (36) 3 (21)
Cumulative frequency of clinical features
 Puffy hands, N (%) 98 (94) 10 (71)a
 Arthritis, N (%) 79 (76) 13 (93)
 Myositis, N (%) 34 (33) 2 (14)
 Raynaud’s phenomenon, N (%) 103 (99) 14 (100)
 Sclerodactily, N (%) 30 (29) 3 (21)
 Leukocytopenia, N (%) 30 (29) 7 (50)
 Thrombocytopenia, N (%) 17 (16) 0
 Facial erythema, N (%) 44 (42) 6 (43)
 Pericarditis, N (%) 10 (10) 1 (7)
 Pleuritis, N (%) 13 (13) 1 (7)
Pulmonary function tests
 Percentage DLCO pred, mean (SD) 74 (17) 80 (14)
 Percentage FVC pred, mean (SD) 92 (18) 99 (14)
Genetics and anti-RNP antibodies at T1
 Anti-RNP, U/mL, median (IQR) 27 (5–66) 104 (25–240)
 HLA DRB1*04:01, N (%) 49 (50) 4 (31)
  1. MCTD mixed connective tissue disease, DCLO pred predicted value of gas diffusing capacity of the lung for carbon monoxide, FVC pred predicted value of forced vital capacity, Anti-RNP anti-ribonucleoprotein
  2. aSignificantly greater proportion of patients with puffy hands (P = .004) in the stable MCTD phenotype group compared to diagnostic converters