From: Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis
 | Inactive SLE (N = 80) | Active non-renal SLE (N = 67) | Active renal SLE (N = 80) | Total (N = 227) | P value* |
---|---|---|---|---|---|
Mean ± SD; number (%) |  | ||||
Age, years | 44.0 ± 12.4 | 35.1 ± 13.9 | 37.8 ± 13.9 | 39.2 ± 13.8 | < 0.001 |
Women | 77 (96) | 62 (93) | 75 (94) | 214 (94) | 0.37 |
SLE duration, years | 12.5 ± 6.6 | 4.0 ± 5.2 | 4.9 ± 5.8 | 7.3 ± 7.0 | < 0.001 |
Clinical disease activity | |||||
 Neuropsychiatric | - | 9 (13) | 5 (6.3) | 14 (6.2) | 0.14 |
 Musculoskeletal | - | 30 (45) | 29 (36) | 59 (26) | 0.29 |
 Renal | - | 0 (0) | 80 (100) | 80 (35) | < 0.001 |
 Mucocutaneous | - | 37 (55) | 26 (33) | 63 (28) | 0.006 |
 Serositis | - | 15 (22) | 14 (18) | 29 (13) | 0.46 |
 Hematological | - | 39 (58) | 19 (24) | 58 (26) | < 0.001 |
Autoantibodies | |||||
 Anti-Sm | 12 (15) | 21 (31) | 21 (26) | 54 (24) | 0.06 |
 Anti-Ro | 48 (60) | 44 (66) | 57 (71) | 149 (66) | 0.37 |
 Anti-La | 11 (14) | 15 (22) | 27 (34) | 53 (23) | 0.01 |
 Anti-nRNP | 20 (25) | 28 (42) | 30 (38) | 78 (34) | 0.09 |
 aPLa | 31 (39) | 27 (40) | 18 (23) | 76 (33) | 0.04 |
SLEDAI | 2.11 ± 1.67 | 10.1 ± 5.51 | 16.0 ± 6.42 | 9.39 ± 7.65 | < 0.001 |
PGA score | 0.21 ± 0.15 | 1.89 ± 0.32 | 2.14 ± 0.21 | 1.39 ± 0.90 | < 0.001 |
SLICC damage score | 0.49 ± 1.20 | 0.69 ± 0.97 | 0.81 ± 1.32 | 0.77 ± 1.18 | 0.98 |
Medications at time of sample collection | |||||
 Prednisolone | 38 (48) | 27 (40) | 41 (51) | 106 (47) | 0.41 |
 Azathioprine | 30 (38) | 8 (12) | 16 (20) | 54 (24) | 0.001 |
 Cyclophosphamide | 0 (0) | 1 (1.5) | 1 (1.3) | 2 (0.9) | 0.57 |
 Cyclosporin A | 3 (3.8) | 2 (3) | 3 (3.8) | 8 (3.5) | 0.96 |
 Tacrolimus | 2 (2.5) | 3 (4.5) | 2 (2.5) | 7 (3) | 0.73 |
 Mycophenolate mofetil | 12 (15) | 6 (9) | 11 (14) | 29 (13) | 0.52 |
 Hydroxychloroquine | 48 (60) | 33 (49) | 35 (44) | 116 (51) | 0.11 |