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Table 1 Clinical characteristics of the patients with SLE in the study

From: Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis

 

Inactive SLE (N = 80)

Active non-renal SLE (N = 67)

Active renal SLE (N = 80)

Total (N = 227)

P value*

Mean ± SD; number (%)

 

Age, years

44.0 ± 12.4

35.1 ± 13.9

37.8 ± 13.9

39.2 ± 13.8

< 0.001

Women

77 (96)

62 (93)

75 (94)

214 (94)

0.37

SLE duration, years

12.5 ± 6.6

4.0 ± 5.2

4.9 ± 5.8

7.3 ± 7.0

< 0.001

Clinical disease activity

 Neuropsychiatric

-

9 (13)

5 (6.3)

14 (6.2)

0.14

 Musculoskeletal

-

30 (45)

29 (36)

59 (26)

0.29

 Renal

-

0 (0)

80 (100)

80 (35)

< 0.001

 Mucocutaneous

-

37 (55)

26 (33)

63 (28)

0.006

 Serositis

-

15 (22)

14 (18)

29 (13)

0.46

 Hematological

-

39 (58)

19 (24)

58 (26)

< 0.001

Autoantibodies

 Anti-Sm

12 (15)

21 (31)

21 (26)

54 (24)

0.06

 Anti-Ro

48 (60)

44 (66)

57 (71)

149 (66)

0.37

 Anti-La

11 (14)

15 (22)

27 (34)

53 (23)

0.01

 Anti-nRNP

20 (25)

28 (42)

30 (38)

78 (34)

0.09

 aPLa

31 (39)

27 (40)

18 (23)

76 (33)

0.04

SLEDAI

2.11 ± 1.67

10.1 ± 5.51

16.0 ± 6.42

9.39 ± 7.65

< 0.001

PGA score

0.21 ± 0.15

1.89 ± 0.32

2.14 ± 0.21

1.39 ± 0.90

< 0.001

SLICC damage score

0.49 ± 1.20

0.69 ± 0.97

0.81 ± 1.32

0.77 ± 1.18

0.98

Medications at time of sample collection

 Prednisolone

38 (48)

27 (40)

41 (51)

106 (47)

0.41

 Azathioprine

30 (38)

8 (12)

16 (20)

54 (24)

0.001

 Cyclophosphamide

0 (0)

1 (1.5)

1 (1.3)

2 (0.9)

0.57

 Cyclosporin A

3 (3.8)

2 (3)

3 (3.8)

8 (3.5)

0.96

 Tacrolimus

2 (2.5)

3 (4.5)

2 (2.5)

7 (3)

0.73

 Mycophenolate mofetil

12 (15)

6 (9)

11 (14)

29 (13)

0.52

 Hydroxychloroquine

48 (60)

33 (49)

35 (44)

116 (51)

0.11

  1. SLE systemic lupus erythematosus, SD standard deviation, SLEDAI SLE disease activity index, aPL antiphospholipid, PGA physician’s global assessment, SLICC SLE International Collaborative Clinic
  2. *P comparison among the three groups
  3. aEither IgG anti-cardiolipin or the lupus anticoagulant