Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis

Table 3 ROC analyses of the cutoff values of the protein markers

Markers	Cutoff	AUC (95% CI)	Specificity	Sensitivity	P value
Active renal vs active non-renal
Angiostatin	> 2.219 ng/ng	0.87 (0.81–0.92)	0.82	0.80	< 0.001
CXCL4	> 1.06 pg/ng	0.64 (0.55–0.73)	0.61	0.63	0.003
VCAM-1	> 668 pg/ng	0.73 (0.65–0.82)	0.66	0.69	< 0.001
Anti-dsDNA	> 208 IU/ml	0.64 (0.55–0.73)	0.64	0.63	0.004
C3	< 0.50 g/L	0.66 (0.58–0.75)	0.61	0.66	0.001
Active vs inactive SLE
Angiostatin	> 0.345 ng/ng	0.85 (0.81–0.90)	0.71	0.78	< 0.001
CXCL4	> 0.085 pg/ng	0.76 (0.70–0.82)	0.88	0.61	< 0.001
VCAM-1	> 179 pg/ng	0.80 (0.75–0.86)	0.73	0.76	< 0.001
Anti-dsDNA	> 159 IU/ml	0.75 (0.69–0.81)	0.65	0.65	< 0.001
C3	< 0.72 g/L	0.82 (0.76–0.87)	0.73	0.74	< 0.001

ROC receiver operating characteristic curve, AUC area under the curve, SLE systemic lupus erythematosus, CI confidence interval, CXCL4 CXC chemokine ligand 4, VCAM-1 vascular cell adhesion molecule-1

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