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Table 3 ROC analyses of the cutoff values of the protein markers

From: Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis

Markers Cutoff AUC (95% CI) Specificity Sensitivity P value
Active renal vs active non-renal
 Angiostatin > 2.219 ng/ng 0.87 (0.81–0.92) 0.82 0.80 < 0.001
 CXCL4 > 1.06 pg/ng 0.64 (0.55–0.73) 0.61 0.63 0.003
 VCAM-1 > 668 pg/ng 0.73 (0.65–0.82) 0.66 0.69 < 0.001
 Anti-dsDNA > 208 IU/ml 0.64 (0.55–0.73) 0.64 0.63 0.004
 C3 < 0.50 g/L 0.66 (0.58–0.75) 0.61 0.66 0.001
Active vs inactive SLE
 Angiostatin > 0.345 ng/ng 0.85 (0.81–0.90) 0.71 0.78 < 0.001
 CXCL4 > 0.085 pg/ng 0.76 (0.70–0.82) 0.88 0.61 < 0.001
 VCAM-1 > 179 pg/ng 0.80 (0.75–0.86) 0.73 0.76 < 0.001
 Anti-dsDNA > 159 IU/ml 0.75 (0.69–0.81) 0.65 0.65 < 0.001
 C3 < 0.72 g/L 0.82 (0.76–0.87) 0.73 0.74 < 0.001
  1. ROC receiver operating characteristic curve, AUC area under the curve, SLE systemic lupus erythematosus, CI confidence interval, CXCL4 CXC chemokine ligand 4, VCAM-1 vascular cell adhesion molecule-1