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Table 4 Performance of the protein markers in differentiating different groups of patients with SLE

From: Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis

Markers Sensitivity Specificity PPV NPV
Active renal vs active non-renal
 Angiostatin 0.80 0.82 0.84 0.77
 CXCL4 0.63 0.61 0.66 0.58
 VCAM-1 0.69 0.66 0.71 0.64
 Anti-dsDNA 0.63 0.64 0.68 0.59
 Low C3 0.61 0.66 0.68 0.59
Active vs inactive SLE
 Angiostatin 0.78 0.71 0.83 0.63
 CXCL4 0.61 0.88 0.90 0.55
 VCAM-1 0.76 0.73 0.83 0.62
 Anti-dsDNA 0.65 0.65 0.78 0.51
 C3 0.74 0.73 0.84 0.61
  1. PPV positive predictive value, NPV negative predictive value, SLE systemic lupus erythematosus, CXCL4 CXC chemokine ligand 4, VCAM-1 vascular cell adhesion molecule-1