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Table 5 Urine protein markers in 68 patients with active lupus nephritis confirmed by renal biopsy

From: Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis

 

ISN/RPS class III/IV ± V lupus nephritis (N = 50)

ISN/RPS class I, II, V lupus nephritis (N = 18)

P value

Urinary angiostatin (ng/ng)

19.0 ± 27.8

17.6 ± 23.0

0.83

Urinary CXCL4 (pg/ng)

9.95 ± 16.7

4.22 ± 7.31

0.06

Urinary VCAM-1 (pg/ng)

1330 ± 1380

1560 ± 1140

0.50

Serum anti-dsDNA (IU/ml)

254 ± 81.2

179 ± 116

0.02

Serum C3 (g/L)

0.43 ± 0.17

0.60 ± 0.26

0.02

Histological activity index

8.9 ± 3.2

1.6 ± 2.0

< 0.001

Histological chronicity index

2.5 ± 0.8

0.9 ± 1.3

0.001

Renal SLEDAI score

9.3 ± 3.1

6.4 ± 2.4

< 0.001

Urinary P/Cr

3.3 ± 2.3

4.1 ± 5.4

0.56

  1. SLEDAI systemic lupus erythematosus disease activity index, CXCL4 CXC chemokine ligand 4, VCAM-1 vascular cell adhesion molecule-1P/Cr protein-to-creatinine ratio, ISN/RPS International Society of Nephrology/Renal Pathology Society