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Table 2 MRI and US findings at baseline and 2 and 12 weeks after starting tocilizumab therapy

From: Ultrasonography and magnetic resonance imaging changes in patients with polymyalgia rheumatica treated by tocilizumab

    

Wilcoxon test P value

Week 0

Week 2

Week 12

Week 0 vs week 2

Week 0 vs week 12

MRI (all four joints)

 Bursitis

8 (6–9)

7 (5–8)

6 (4–7)

0.109

0.005*

 Effusion/synovitis

7 (5–9)

7 (6–9)

7 (5.5–7)

0.719

0.231

MRI (both shoulders)

 Bursitis

4 (2–4)

4 (3–4)

3.5 (2–4)

1.000

0.406

 Effusion/synovitis

4 (3–5)

4 (3–5)

3.5 (3–4)

0.625

0.176

MRI (both hips)

 Bursitis

4 (3–6)

3 (2–4)

2 (1.5–3)

0.031*

< 0.001*

 Effusion/synovitis

4 (2–4)

4 (3–4)

3 (2–4)

1.000

0.117

US (all four joints)

 Bursitis

2 (1–3)

3 (1–3)

0.5 (0–2)

0.575

0.029*

 Effusion/synovitis

3 (2–5)

3.5 (2–5)

2 (1–3)

1.000

0.001*

US (both shoulders)

 Bursitis

2 (1–3)

2 (0–3)

0.5 (0–1)

0.542

0.018*

 Effusion/synovitis

2 (1–3)

2.5 (1–4)

1 (1–2)

0.781

0.059

US (both hips)

 Bursitis

0 (0–1)

0 (0–0)

0 (0–0)

1.000

0.625

 Effusion/synovitis

2 (0–3)

1 (0–2)

0 (0–2)

0.560

0.002*

  1. Data are median (interquartile range)
  2. MRI magnetic resonance imaging US ultrasonography
  3. *Significant differences, Wilcoxon signed-rank test (P < 0.05)