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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?

Fig. 1

Simplified scheme of the induction of interferon (IFN) type I production by three signaling pathways: (1) endosomal receptors toll-like receptor (TLR)7 and TLR9; (2) RNA-binding cytosolic receptors MDA5 and RIG-I; and (3) DNA-binding receptors ZBP1 and IFI16. These pathways contribute to the activation of interferon regulatory factors (IRFs), which induce the expression of type I IFNs. Binding of IFN to cells that express the interferon alpha receptor (IFNAR) activates a cascade that leads to the expression of various IFN-stimulated genes (ISGs), known as the IFN type I signature

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