Fig. 1From: Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?Simplified scheme of the induction of interferon (IFN) type I production by three signaling pathways: (1) endosomal receptors toll-like receptor (TLR)7 and TLR9; (2) RNA-binding cytosolic receptors MDA5 and RIG-I; and (3) DNA-binding receptors ZBP1 and IFI16. These pathways contribute to the activation of interferon regulatory factors (IRFs), which induce the expression of type I IFNs. Binding of IFN to cells that express the interferon alpha receptor (IFNAR) activates a cascade that leads to the expression of various IFN-stimulated genes (ISGs), known as the IFN type I signatureBack to article page