Fig. 2

a Prevalence of the interferon (IFN) type I signature in patients with childhood-onset systemic lupus erythematosus (cSLE). Dotted line indicates the cutoff value of 10 for discrimination between IFN-negative (IFNneg) and IFN-positive (IFNpos) subjects. b Relative MxA expression was calculated as (MxA-specific staining patient (MFI)-isotype control patient (MFI))/(MxA-specific staining healthy control (HC) (MFI)-isotype control HC (MFI)). MxA is shown for HCs, IFN neg and IFN pos patients with cSLE. c MxA levels (ug/l) determined by MxA-enzyme immunoassays (EIA) in whole-blood lysates of HCs and patients with cSLE. Dotted line indicates the cutoff value of 50 for discrimination between IFN neg and IFN pos subjects. Every symbol represents one subject; horizontal lines describe the medians; groups were compared using one-way analysis of variance (three groups): *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001