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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?

Fig. 4

Upregulated protein expression of RIG-I and ZBP-1 in interferon (IFN)-positive CD14+ monocytes from patients with childhood-onset systemic lupus erythematosus (cSLE). Flow cytometric analysis of MDA5, RIG-I, IFI16 and ZBP-1 in CD14+ monocytes from IFN-positive (IFNpos) patients with cSLE (n = 8), IFN-negative (IFNneg) patients with cSLE (n = 8) and healthy controls (HCs) (n = 8). Each symbol represents an individual sample. The Kruskal-Wallis test was used to compare the three groups. Data are represented as fold change (FC) compared to HCs: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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