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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Synovial IL-9 facilitates neutrophil survival, function and differentiation of Th17 cells in rheumatoid arthritis

Fig. 3

Effect of IL-9 on neutrophil activation and IL-9R expression. a Cumulative bar graph shows IL-9R on neutrophils under different stimulation (rIL-9, LPS, LPS + rIL-9, n = 6, mean ± SEM). b Histogram plot shows higher expression of IL-9R on SF-derived (dark open line) neutrophils than PBL neutrophils of RA patients (light open line, dark area is control isotype), cumulative bar graph shows IL-9 receptor expression on neutrophils of RA patients; PBL and SF, n = 7).c CD69 expression on neutrophils under different culture conditions (rIL-9, LPS, LPS + rIL-9, n = 6, mean ± SEM). d One representative FACS histogram plot of six individual experiments shows intracellular MMP-9 in the presence of rIL-9 (light open line), SF (dark open line, untreated in dark shaded area). e Soluble MMP-9 level in plasma (HC; n = 15, OA; n = 10, RA; n = 17) and SF (OA; n = 10, RA; n = 17, unpaired t test, mean ± SEM *p < 0.05, **p < 0.001, ***p < 0.0001). HC healthy control, IL-9R interleukin 9 receptor, LPS lipopolysaccharide, MMP-9 matrix metalloproteinase-9, OA osteoarthritis, RA rheumatoid arthritis, SF synovial fluid

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