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Table 2 Univariate and multivariate association of relevant patient characteristics with the outcome: absence of DAS28 remission at 12 months

From: Can baseline ultrasound results help to predict failure to achieve DAS28 remission after 1 year of tight control treatment in early RA patients?

Variable

Univariate

Multivariate

OR (95% CI)

P value

OR (95% CI)

P value

DAS28 per point

1.34 (1.03–1.73)

0.03

1.60 (1.18–2.2)

0.002

Female gender

1.94 (0.96–3.3.9)

0.06

1.93 (0.91–4)

0.09

RF positive

1.78 (0.87–3.63)

0.11

2.34 (1.07–5.1)

0.03

aCCP positive

1.54 (0.79–3)

0.21

  

RF and aCCP positive

1.59 (0.83–3)

0.17

 

Age per year

1.01 (0.99–1.04)

0.24

 

Monitoring strategy

 Sub-cohort A

Reference

NA

Reference

NA

 Sub-cohort B

0.49 (0.13–1.73)

0.27

0.20 (0.05–0.85)

0.03

 Sub-cohort C

1.26 (0.47–3.39)

0.64

0.68 (0.20–2.4)

0.55

 Sub-cohort D

1.26 (0.26–1.48)

0.28

0.85 (0.30–2.4)

0.76

Symptom duration (months)

1.0 (0.91–1.1)

0.99

  

SvH per point

1.04 (0.93–1.15)

0.48

 

Smoking yes/no

1.56 (0.73–3.4)

0.25

 

HAQ per point

1.16 (0.71–1.9)

0.55

 

USJC per point

0.99 (0.92–1.06)

0.77

0.96 (0.89–1.04)

0.31

  1. Absence of remission = 1
  2. Ultrasound joint count (USJC) = number of joints with at least greyscale (GS) > 1 or power Doppler (PD) > 0
  3. Multivariate model including: DAS28 at baseline, RF, monitor strategy, gender, and USJC
  4. Monitor strategies: Sub-cohort A, monitoring at least every 3 months and treatment escalation at the discretion of the physician; sub-cohort B, monitoring every 4 weeks and treatment escalation if no remission; sub-cohort C, monitoring varies between 4 and 12 weeks and treatment escalation if no remission, prespecified in a protocol [24]; sub-cohort D, monitoring every 3 months and treatment escalation if no low-disease activity [23]
  5. aCCP anti-cyclic citrullinated peptide, CI confidence interval, DAS Disease Activity Score, HAQ Health Assessment Questionnaire, NA not applicable, OR odds ratio, RF rheumatoid factor, SvH Sharp-van der Heijde