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Table 2 Demographics and cognitive test scores (HC/nonNPSLE/NPSLE patients)

From: Altered white matter microstructure in lupus patients: a diffusion tensor imaging study

   

p value

  

NonNPSLE patients (n = 25)

NPSLE patients (n = 39)

HC/nonNPSLE

HC/NPSLE

NonNPSLE/NPSLE

Demographics

 MADRS-S

7.8 (4.9–10.7)

15.6 (12.5–18.6)

0.036*

0.000**

0.000**

 Duration

11.2 (8.1–14.4)

11.8 (9.1–14.5)

  

0.783

 SDI

0.5 (0.1–0.9)

0.8 (0.4–1.2)

  

0.312

 FSS

38 (32–43)

43 (38–49)

0.000**

0.000**

0.140

 SLEDAI-2k

2 (0.9–3.1)

2.7 (1.5–3.8)

  

0.430

 Age

36.0 (32.4–39.7)

37.5 (34.6–40.3)

0.646

0.925

0.524

 Daily dose of GCs

4.6 (2.9–6.2)

5.4 (3.7–7.0)

  

0.510

Cognitive domain

 Memory domain

99 (91–105)

93 (88–98)

0.421

0.033*

0.170

 Psychomotor speed

100.1 (96–105)

93 (90–97)

0.090

0.000**

0.016**

 Reaction time

92 (85–98)

87(80–95)

0.317

0.063

0.399

 Complex attention

106 (101–111)

89 (81–98)

0.997

0.003**

0.001**

 Cognitive flexibility

105 (98–112)

89 (82–97)

0.935

0.004**

0.002**

  1. Data presented as mean (95% confidence interval). Characteristics of patients and controls in the cohort after exclusions. Healthy controls (n = 20); nonNPSLE patients (n = 25); NPSLE patients (n = 39)
  2. HC healthy controls, NPSLE neuropsychiatric systemic lupus erythematosus, MADRS-S Montgomery Asberg Depression Rate Score Self-report, SDI Systemic Lupus International Collaborating Clinical/ACR Organ Damage Index, FSS Fatigue Severity Score, SLEDAI-2k SLE Disease Activity Index-2000, GC glucocorticoids
  3. *p < 0.05
  4. **p < 0.01