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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: A unique role for galectin-9 in angiogenesis and inflammatory arthritis

Fig. 1

Galectin-9 medium (Gal-9 M) induces human dermal microvascular endothelial cell (HMVEC) migration in vitro. a Gal-9 M induced HMVEC migration at concentrations between 2.79 nmol/L and 55.8 nmol/L (p < 0.0001). n Number of the replicates in each group. b HMVEC chemotaxis with various signaling inhibitors. Signaling inhibitors of Janus kinase (Jnk), extracellular signal-regulating kinases 1/2 (Erk1/2), and p38 significantly reduced Gal-9 M-stimulated HMVEC chemotaxis compared with the control group (p < 0.05). n Number of experiments. c A chemotaxis assay was performed with HMVECs transfected with Erk1/2 and p38 small interfering RNA (siRNA) for 48 h. HMVECs transfected with Erk1/2 and p38 siRNAs had significantly less migration in response to Gal-9 M (p < 0.05). n Number of replicates in each group. bFGF Basic fibroblast growth factor, DMSO Dimethyl sulfoxide, HPF High-power field, PI3K Phosphatidylinositol 3-kinase

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