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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells

Fig. 3

T helper type 2 cell (Th2)-like regulatory T cells (Tregs) are induced by coculture with Fli1+/− dermal fibroblasts through interleukin (IL)-33. a Evaluation by flow cytometry of Th1-, Th2-, and Th17-like Treg induction by coculture with wild-type (WT) and Fli1+/− dermal fibroblasts (n = 6). b Evaluation by flow cytometry of the effect of IL-33-neutralizing antibody on Tregs cocultured with Fli1+/− dermal fibroblasts (n = 6). Representative plots of interferon (IFN)-γ-, IL-4-, and IL-17A-positive Tregs are shown in right upper panels of (a) and (b). Gating strategy for identification of CD4+FoxP3+ Tregs is shown in the leftmost panels of (a) and (b). In each graph, the relative value compared with the control group is expressed as mean ± SEM. AU Arbitrary units, Fli1 Friend leukemia virus integration 1

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