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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice

Fig. 4

Comparisons of mRNA expression levels of receptor activator of NF-κB (RANK), RANK ligand (RANKL), osteoprotogerin (OPG), RANKL/OPG ratio, monocyte chemotactic protein-1 (MCP-1), regulated on activation, normal T cell expressed and secreted (RANTES), CX3CL1, TNFα, IL-6, IL-17, and IL-10 in the ankle joints analyzed by qRT-PCR among untreated, normal rat IgG-treated, and monoclonal antibody (5C6)-treated FcγRIIB-deficient mouse strain (KO1) mice at 10 months of age. Values in each of the three groups of mice were evaluated as fold change compared with the expression levels in B6 mice (broken line). Data are shown as mean + SEM of six mice from each group. Statistical significance is shown (analysis of variance *P < 0.05, **P < 0.01, *** P < 0.001)

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