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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice

Fig. 5

Comparisons of mRNA expression levels of B-cell-activating factor of the tumor-necrosis-factor family (BAFF), IL-1β, B cell stimulating factor-3 (BSF-3), IL-6, IL-10, IL-17, interferon-γ (IFN-γ), and TNFα in spleen (a) and peripheral leukocytes (b) analyzed by qRT-PCR among untreated, normal rat IgG-treated, and monoclonal antibody (5C6)-treated FcγRIIB-deficient mouse strain (KO1) mice at 10 months of age. Values of each of the three groups of mice were evaluated as fold change compared with the expression levels in B6 mice (broken line). Data are shown as mean + SEM of six mice from each group. Statistical significance is shown (analysis of variance *P < 0.05, **P < 0.01, *** P < 0.001)

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Arthritis Research & Therapy

ISSN: 1478-6362

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