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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis

Fig. 5

Reduced expression of osteopontin (OPN) and tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts in adiponectin (AD)-treated collagen-induced arthritis (CIA) mice with Lenti-shOPN administration. a Serially sectioned immunohistochemical staining of OPN in the ankle joint tissue of AD-treated CIA mice with or without Lenti-shOPN on day 45 post the 1st collagen type II (CII) immunization (magnification ×20 and ×40). OPN-expressing cells were stained with intense brown color. b Serially sectioned immunohistochemical TRAP staining in the ankle joint tissue of AD-treated CIA mice with or without Lenti-shOPN on day 45 post the 1st CII immunization (magnification ×20 and ×40). TRAP-positive osteoclasts were stained red (n = 5). The results shown are representative of one of three independent experiments. Bars show the mean ± SD (*p < 0.05)

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