Fig. 6
Co-localization of osteopontin (OPN) and integrin αvβ3 in adiponectin (AD)-treated collagen-induced arthritis (CIA) mice administered or not administered Lenti-shOPN. Double immunofluorescence analysis of OPN and integrin αvβ3 expression in the ankle joint tissue of AD-treated CIA mice with or without Lenti-shOPN injection on day 45 post the 1st collagen type II (CII) immunization (n = 5). Each section was merged with 4’,6-diamidino-2-phenylindole (DAPI) (magnification ×20)