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Table 3 Demographic data of study subjects used in co-culture experiments

From: Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis

  Healthy control subjects (n = 5) Individuals with RA risk (n = 5) Patients with early RAa (n = 5)
Passages P4–P8 P4–P8 P4–P8
Female sex, n (%) 3 (60) 3 (60) 4 (80)
Median age, years (IQR) 28 (24–33) 50 (28–57) 47 (35–57)
IgM-RF-positive, n (%) 0 (0) 0 (0) 4 (80)
IgM-RF level, kU/L, median (IQR) 3 (1–15.5) 437 (159–2210)
ACPA-positive, n (%) 0 (0) 5 (100) 5 (100)
ACPA level, kAU/L, median (IQR) 75 (45–112.5) 328 (61–1969)
IgM-RF and ACPA both positive, n (%) 0 (0) 0 (0) 4 (80)
DAS28, median (IQR) 5.3 (3.2–6.8)
CRP, mg/L, median (IQR) 0.4 (0.3–2.7) 1.6 (0.7–2) 4.4 (1.3–19.8)
  1. Abbreviations: ACPA anti-citrullinated protein antibodies, kAU/L kilo arbitrary Unit/L, CRP C-reactive protein, DAS28 disease activity score in 28 joints, IgM-RF immunoglobulin M-rheumatoid factor, kU/L kilo Unit/L, RA rheumatoid arthritis
  2. a Patients with early RA: naïve for disease-modifying anti-rheumatic drugs and biologics with a disease duration (defined by arthritis in any joint) less than 1 year