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Table 1 High IgG anti-MDA serum levels are associated with disease activity in two independent cohorts

From: Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

  US cohort Karolinska cohort Meta-analysis
  SLEDAI< 6 SLEDAI≥ 6 OR(95% CI) p valuea SLEDAI< 6 SLEDAI≥ 6 OR(95% CI) p valuea OR(95% CI) p valueb
IgG anti-dsDNA positive % (n/N) 47/165 20/28 6.21(2.4–17.5) < 0.0001 73/270 77/126 4.24(2.7–6.7) < 0.0001 4.60(3.1–6.9) < 0.0001
IgG anti-MDA positive % (n/N)c 59/175 25/44 2.59(1.3–5.1) 0.006 84/270 70/126 2.77(1.8–4.3) < 0.0001 2.71(1.9–3.9) < 0.0001
  1. The Karolinska cohort used the 2K [26] version and the US cohort used the SELENA [30] version of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Significant p values are highlighted in bold
  2. CI confidence interval, dsDNA double-stranded DNA, Ig immunoglobulin, MDA malondialdehyde, n number of positive patients, N total number of patients with available data, OR odds ratio
  3. aFisher’s exact test
  4. bMantel-Haenszel fixed effect model
  5. cCutoff for anti-MDA was based on the highest quartile, 75th percentile of corresponding controls, 10.5 NYU-RU/ml for the US cohort and 42 KI-RU/ml for the Swedish Karolinska cohort. Cutoff for IgG anti-dsDNA was according to the clinical assay’s instruction