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Table 1 High IgG anti-MDA serum levels are associated with disease activity in two independent cohorts

From: Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

 

US cohort

Karolinska cohort

Meta-analysis

 

SLEDAI< 6

SLEDAI≥ 6

OR(95% CI)

p valuea

SLEDAI< 6

SLEDAI≥ 6

OR(95% CI)

p valuea

OR(95% CI)

p valueb

IgG anti-dsDNA positive % (n/N)

47/165

20/28

6.21(2.4–17.5)

< 0.0001

73/270

77/126

4.24(2.7–6.7)

< 0.0001

4.60(3.1–6.9)

< 0.0001

IgG anti-MDA positive % (n/N)c

59/175

25/44

2.59(1.3–5.1)

0.006

84/270

70/126

2.77(1.8–4.3)

< 0.0001

2.71(1.9–3.9)

< 0.0001

  1. The Karolinska cohort used the 2K [26] version and the US cohort used the SELENA [30] version of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Significant p values are highlighted in bold
  2. CI confidence interval, dsDNA double-stranded DNA, Ig immunoglobulin, MDA malondialdehyde, n number of positive patients, N total number of patients with available data, OR odds ratio
  3. aFisher’s exact test
  4. bMantel-Haenszel fixed effect model
  5. cCutoff for anti-MDA was based on the highest quartile, 75th percentile of corresponding controls, 10.5 NYU-RU/ml for the US cohort and 42 KI-RU/ml for the Swedish Karolinska cohort. Cutoff for IgG anti-dsDNA was according to the clinical assay’s instruction
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Arthritis Research & Therapy

ISSN: 1478-6362

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