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Table 2 IgG anti-MDA levels are elevated in patients with nephritis

From: Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

  No nephritisa (N = 241) Nephritis (N = 148) OR (95% CI) p value b Adjusted p value c
Female, % (n/N) 92% (221/241) 83% (123/148) 0.45 (0.23–0.83) 0.01 N/A
Age (years) 47.8 ± 15.4 45.5 ± 14.4 N/A NS (0.12) N/A
Disease duration (years) 12.8 ± 12.2 13.9 ± 11.6 N/A NS (0.18) N/A
ESR (mm/h) 25.4 ± 19.7 27.8 ± 22.8 N/A NS (0.50) NS (0.34)
hsCRP (μg/ml) 5.0 ± 10.2 4.3 ± 6.4 N/A NS (0.85) NS (0.74)
Total IgG (mg/ml) 14.9 ± 6.0 12.9 ± 4.5 N/A < 0.0001 < 0.0001
IgG anti-dsDNA/total IgG (RU/mg) 1.5 ± 3.5 3.4 ± 6.6 N/A < 0.0001 N/A
IgG anti-PC/total IgG (KI-RU/mg) 4.7 ± 4.1 5.2 ± 4.4 N/A NS (0.16) NS (0.25)
IgG anti-MDA/total IgG (KI-RU/mg) 3.4 ± 3.3 4.5 ± 4.0 N/A < 0.0001 0.04
Positive dsDNA IgG (> 10 RU/ml) 31% (74/240) 49% (72/148) 2.1 (1.4–3.2) 0.0005 N/A
High IgG anti-MDA/total IgG (> 3.8 KI-RU/mg) 26% (62/241) 42% (62/148) 2.1 (1.3–3.2) 0.001 0.02
  1. Values are shown as mean ± SD or % (n/N)
  2. CI confidence interval, dsDNA double-stranded DNA, ESR erythrocyte sedimentation rate, hsCRP high-sensitivity C-reactive protein, Ig immunoglobulin, MDA malondialdehyde, n number of positive patients, N total number of patients with available data, N/A not available, NS not significant, OR odds ratio, PC phosphorylcholine, RU relative units Significant p values are highlighted in bold
  3. aNephritis was defined according to the 1982 revised ACR criteria, by proteinuria > 5 g per day or greater than 3+ by dipstick if quantification was not performed, and/or cellular casts [25]
  4. bp value from Mann-Whitney analysis (continuous variables) or Fisher’s exact test (frequencies)
  5. cp value adjusted for sex, age, disease duration, and IgG anti-dsDNA levels
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