| |
No nephritisa (N = 241)
|
Nephritis (N = 148)
|
OR (95% CI)
|
p value
b
|
Adjusted p value
c
|
|---|
|
Female, % (n/N)
|
92% (221/241)
|
83% (123/148)
|
0.45 (0.23–0.83)
|
0.01
|
N/A
|
|
Age (years)
|
47.8 ± 15.4
|
45.5 ± 14.4
|
N/A
|
NS (0.12)
|
N/A
|
|
Disease duration (years)
|
12.8 ± 12.2
|
13.9 ± 11.6
|
N/A
|
NS (0.18)
|
N/A
|
|
ESR (mm/h)
|
25.4 ± 19.7
|
27.8 ± 22.8
|
N/A
|
NS (0.50)
|
NS (0.34)
|
|
hsCRP (μg/ml)
|
5.0 ± 10.2
|
4.3 ± 6.4
|
N/A
|
NS (0.85)
|
NS (0.74)
|
|
Total IgG (mg/ml)
|
14.9 ± 6.0
|
12.9 ± 4.5
|
N/A
|
< 0.0001
|
< 0.0001
|
|
IgG anti-dsDNA/total IgG (RU/mg)
|
1.5 ± 3.5
|
3.4 ± 6.6
|
N/A
|
< 0.0001
|
N/A
|
|
IgG anti-PC/total IgG (KI-RU/mg)
|
4.7 ± 4.1
|
5.2 ± 4.4
|
N/A
|
NS (0.16)
|
NS (0.25)
|
|
IgG anti-MDA/total IgG (KI-RU/mg)
|
3.4 ± 3.3
|
4.5 ± 4.0
|
N/A
|
< 0.0001
|
0.04
|
|
Positive dsDNA IgG (> 10 RU/ml)
|
31% (74/240)
|
49% (72/148)
|
2.1 (1.4–3.2)
|
0.0005
|
N/A
|
|
High IgG anti-MDA/total IgG (> 3.8 KI-RU/mg)
|
26% (62/241)
|
42% (62/148)
|
2.1 (1.3–3.2)
|
0.001
|
0.02
|
- Values are shown as mean ± SD or % (n/N)
- CI confidence interval, dsDNA double-stranded DNA, ESR erythrocyte sedimentation rate, hsCRP high-sensitivity C-reactive protein, Ig immunoglobulin, MDA malondialdehyde, n number of positive patients, N total number of patients with available data, N/A not available, NS not significant, OR odds ratio, PC phosphorylcholine, RU relative units Significant p values are highlighted in bold
- aNephritis was defined according to the 1982 revised ACR criteria, by proteinuria > 5 g per day or greater than 3+ by dipstick if quantification was not performed, and/or cellular casts [25]
- bp value from Mann-Whitney analysis (continuous variables) or Fisher’s exact test (frequencies)
- cp value adjusted for sex, age, disease duration, and IgG anti-dsDNA levels
