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Table 2 IgG anti-MDA levels are elevated in patients with nephritis

From: Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

 

No nephritisa (N = 241)

Nephritis (N = 148)

OR (95% CI)

p value b

Adjusted p value c

Female, % (n/N)

92% (221/241)

83% (123/148)

0.45 (0.23–0.83)

0.01

N/A

Age (years)

47.8 ± 15.4

45.5 ± 14.4

N/A

NS (0.12)

N/A

Disease duration (years)

12.8 ± 12.2

13.9 ± 11.6

N/A

NS (0.18)

N/A

ESR (mm/h)

25.4 ± 19.7

27.8 ± 22.8

N/A

NS (0.50)

NS (0.34)

hsCRP (μg/ml)

5.0 ± 10.2

4.3 ± 6.4

N/A

NS (0.85)

NS (0.74)

Total IgG (mg/ml)

14.9 ± 6.0

12.9 ± 4.5

N/A

< 0.0001

< 0.0001

IgG anti-dsDNA/total IgG (RU/mg)

1.5 ± 3.5

3.4 ± 6.6

N/A

< 0.0001

N/A

IgG anti-PC/total IgG (KI-RU/mg)

4.7 ± 4.1

5.2 ± 4.4

N/A

NS (0.16)

NS (0.25)

IgG anti-MDA/total IgG (KI-RU/mg)

3.4 ± 3.3

4.5 ± 4.0

N/A

< 0.0001

0.04

Positive dsDNA IgG (> 10 RU/ml)

31% (74/240)

49% (72/148)

2.1 (1.4–3.2)

0.0005

N/A

High IgG anti-MDA/total IgG (> 3.8 KI-RU/mg)

26% (62/241)

42% (62/148)

2.1 (1.3–3.2)

0.001

0.02

  1. Values are shown as mean ± SD or % (n/N)
  2. CI confidence interval, dsDNA double-stranded DNA, ESR erythrocyte sedimentation rate, hsCRP high-sensitivity C-reactive protein, Ig immunoglobulin, MDA malondialdehyde, n number of positive patients, N total number of patients with available data, N/A not available, NS not significant, OR odds ratio, PC phosphorylcholine, RU relative units Significant p values are highlighted in bold
  3. aNephritis was defined according to the 1982 revised ACR criteria, by proteinuria > 5 g per day or greater than 3+ by dipstick if quantification was not performed, and/or cellular casts [25]
  4. bp value from Mann-Whitney analysis (continuous variables) or Fisher’s exact test (frequencies)
  5. cp value adjusted for sex, age, disease duration, and IgG anti-dsDNA levels